Elevated resting heart rate is an independent predictor of all-cause death and cardiovascular events in Japanese ambulatory hemodialysis patients.

Clinical and Experimental Nephrology
Taku InoueKunitoshi Iseki

Abstract

Elevated heart rate (HR) is an independent risk factor for all-cause death or cardiovascular events in non-hemodialysis subjects; however, the clinical significance of elevated HR in hemodialysis patients is not well studied. We prospectively evaluated the relationship between HR and adverse outcome in a total of 229 ambulatory hemodialysis patients (57 % men; mean age 62.2 years) recruited from two dialysis clinics in 2009. Mean (SD) HR of this cohort was 74.1 (11.0) beats per minute (bpm). Receiver operating characteristic curves identified an HR cut-off level of ≥80 bpm for increased adverse outcome. After a mean follow-up of 525 days (range 7-760 days) a total of 30 primary endpoints (21 all-cause deaths, 4 acute coronary syndromes and 8 strokes) and 38 secondary endpoints (30 primary endpoints, 8 congestive heart failures, and 5 other cardiovascular events) were detected. Cox regression analysis revealed that HR >80 bpm was not an independent predictor of primary endpoints [hazard ratio 1.81, 95 % confidence interval (CI) 0.79-4.11, p = NS], but of secondary endpoints (hazard ratio 2.01, 95 % CI 1.01-4.22, p < 0.05) after adjusting for age, sex, hemodialysis duration, and cardiovascular risks. Elevated HR is an independent...Continue Reading

References

Jan 1, 1997·Journal of Hypertension·P Palatini, S Julius
Dec 18, 1998·Journal of Hypertension·G GrassiG Mancia
Mar 25, 1999·Archives of Internal Medicine·P PalatiniA C Pessina
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K IsekiK Fukiyama
Nov 22, 2001·Japanese Circulation Journal·T InoueS Takishita
Oct 10, 2002·Kidney International·Robert N FoleyUNKNOWN United States Renal Data System
May 14, 2003·Journal of the American College of Cardiology·Gennaro CiceRaffaele Calabrò
Jul 8, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·B Linnemann, H U Janka
Aug 27, 2005·International Journal of Impotence Research·T I-S HwangH-E Chen
Oct 6, 2006·Kidney International·G L BakrisE Ritz
Jan 18, 2008·International Journal of Cardiology·Keiko OikawaHaruki Itoh
Jan 20, 2009·American Journal of Hypertension·Yoshiyuki ShigetohTsutomu Imaizumi
Feb 6, 2009·BMJ : British Medical Journal·Judith HsiaUNKNOWN Women's Health Initiative Research Group
Apr 16, 2009·Diabetes Care·Susanne R de RooijUNKNOWN Relationship Between Insulin Sensitivity and Cardiovascular Disease (RISC) Investigators
May 16, 2009·Clinical and Experimental Nephrology·Taku InoueShuichi Takishita
Aug 13, 2009·Nephron. Clinical Practice·K IsekiUNKNOWN Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy
Sep 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kunitoshi IsekiUNKNOWN Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy

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Citations

Aug 24, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Taku InoueYusuke Ohya
Jan 8, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rachael Lisa MortonAlan Cass
Jul 15, 2015·PloS One·Congliang MiaoXinchun Yang
Jun 18, 2019·International Heart Journal·Xiao LiuKui Hong

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