PMID: 25760073Mar 12, 2015Paper

Elevated S100A6 (Calcyclin) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma

Oncotarget
Xiangjun LyuXu Zhang

Abstract

Clear cell renal cell carcinoma (ccRCC) is often resistant to existing therapy. We found elevated S100A6 levels in ccRCC tissues, associated with higher grade pathological features and clinical stages in ccRCC patients. Knockdown of S100A6 inhibited cell proliferation in vitro and tumor growth in vivo. Gene expression profiling suggests a novel function of S100A6 in suppressing apoptosis, as well as a relationship between S100A6 and CXCL14, a pro-inflammatory chemokine. We suggest that the S100A6/CXCL14 signaling pathway is a potential therapeutic target in ccRCC.

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Citations

Mar 17, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yaoming PengJun Lin
Jun 20, 2020·Archives of Physiology and Biochemistry·Yuanguang LiuHuizhong Zhang
Oct 7, 2016·Clinical and Translational Medicine·Sven H LoosenTom Luedde
Apr 19, 2017·Cellular and Molecular Life Sciences : CMLS·Rosario DonatoIleana Giambanco
Mar 27, 2020·Molecular Carcinogenesis·Joseph A WestrichDohun Pyeon
Jan 7, 2016·Journal of Inflammation·Jing LuMeinrad Gawaz
Jan 5, 2017·Scientific Reports·Shizhen ZhangXiaochen Wang
Oct 10, 2020·World Journal of Clinical Oncology·Dumitru Andrei Iacobas
May 2, 2021·International Immunopharmacology·Arezoo Gowhari ShabgahJamshid Gholizadeh Navashenaq

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