Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery

American Journal of Obstetrics and Gynecology
K D WenstromS P Cliver

Abstract

Our purpose was to determine whether early second-trimester amniotic fluid interleukin-6 levels predict delivery before 34 weeks' gestation. We used stored second-trimester amniotic fluid samples obtained from women undergoing genetic amniocentesis from 1988 to 1996. Interleukin-6 levels were measured by enzyme-linked immunosorbent assay in samples from every case known to result in delivery from 20 to 34 weeks' gestation (n = 290), and 290 matched controls delivering at > or =37 weeks. Fetal aneuploidies, anomalies, and all cases delivering within 30 days of the amniocentesis (which were thought to be possibly procedure related) were excluded. Interleukin-6 levels were higher in cases than controls (1.9 +/- 5.2 vs 1.0 +/- 2.4 ng/ml, p = 0.004). Cases were grouped according to whether the preterm delivery was indicated or spontaneous: The mean interleukin-6 levels were significantly higher than controls in the spontaneous group (1.6 +/- 3.2 vs 0.8 +/- 1.2 ng/ml, p = 0.01) but not in the indicated group (1.4 +/- 4.0 vs 0.8 +/- 1.2 ng/ml, p = 0.12). In all samples the interleukin-6 level was negatively correlated with the gestational age at delivery (R = -0.11633, p = 0.007). Elevated early second-trimester amniotic fluid interle...Continue Reading

References

May 1, 1992·American Journal of Obstetrics and Gynecology·R S GibbsR L Sweet
Jan 1, 1990·American Journal of Obstetrics and Gynecology·S W WenS P Cliver
Oct 13, 1988·The New England Journal of Medicine·S L HillierD A Eschenbach
Aug 1, 1993·American Journal of Obstetrics and Gynecology·R S Gibbs
Apr 1, 1996·Obstetrics and Gynecology·K ReisenbergerP Husslein
Oct 1, 1996·American Journal of Obstetrics and Gynecology·K D WenstromG P Hemstreet

❮ Previous
Next ❯

Citations

Apr 22, 2014·Antioxidants & Redox Signaling·Stefano Raffaele GiannubiloLaura Mazzanti
Aug 19, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·S Grisaru-GranovskyA Samueloff
Jan 21, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·M YamamotoJ C Lo
Mar 25, 2006·American Journal of Respiratory and Critical Care Medicine·Machiko IkegamiJeffrey A Whitsett
Aug 5, 2006·American Journal of Respiratory Cell and Molecular Biology·Kristina BryUrpo Lappalainen
Jun 19, 2007·BMC Pregnancy and Childbirth·Piotr LaudanskiTadeusz Laudanski
Apr 28, 2009·Current Opinion in Infectious Diseases·Catalin S BuhimschiIrina A Buhimschi
May 5, 2009·American Journal of Respiratory Cell and Molecular Biology·Erica BäckströmKristina Bry
Oct 1, 2011·Journal of Perinatal Medicine·Roberto RomeroMoshe Mazor
Jan 27, 2011·Journal of Perinatal Medicine·Byoung Jae KimBo Hyun Yoon
May 3, 2013·Journal of Periodontology·Bryan S MichalowiczKåre Buhlin
Oct 19, 2002·Journal of Reproductive Immunology·Suzanne M GarlandRoy Robins-Browne
Jun 9, 2000·Annual Review of Physiology·A H Jobe, M Ikegami
Aug 7, 2012·American Journal of Respiratory Cell and Molecular Biology·Anna HogmalmKristina Bry
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Apr 2, 2003·Seminars in Neonatology : SN·Alan H Jobe
Sep 4, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sun Min KimBo Hyun Yoon
Dec 9, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sun Min KimBo Hyun Yoon
Dec 5, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hambak LeeIn Yang Park
Sep 29, 2011·Seminars in Fetal & Neonatal Medicine·Varkha Agrawal, Emmet Hirsch
Mar 15, 2016·International Journal of Obstetric Anesthesia·A ChauL C Tsen
Jun 24, 2010·Clinics in Perinatology·Irina A Buhimschi, Catalin S Buhimschi
Dec 1, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nikolaos ThomakosAris Antsaklis
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Chong Jai KimYeon Mee Kim
May 28, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Ramkumar MenonCarol J Hogue
Mar 16, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·A Conde-AgudeloJ Villar
Mar 17, 2016·American Journal of Obstetrics and Gynecology·Heather A FreyGeorge A Macones
Jan 13, 2004·Clinics in Perinatology·Jay D Iams
Sep 26, 2008·Journal of Reproductive Immunology·Julia Warner GarganoHwan Chung
Oct 21, 2003·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Mary Lou Moore
Feb 20, 2007·Annals of the New York Academy of Sciences·Ariadne Malamitsi-PuchnerDimitrios Hassiakos
Jan 9, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·R RomeroM Mazor
Nov 16, 2007·The Journal of Obstetrics and Gynaecology Research·Hiroshi AnbeRobert E Garfield
Nov 13, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·G DaskalakisA Antsaklis
May 17, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Lene Hee
May 3, 2013·Journal of Clinical Periodontology·Bryan S MichalowiczKåre Buhlin
Jun 12, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Monique HoWilliam W Andrews
Jul 26, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Christina FotopoulouChristian Bamberg
Aug 24, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tayfur CiftAli Benian
Oct 18, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sun Min KimBo Hyun Yoon
Jul 6, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Christian BambergKarim D Kalache

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Obstetrics and Gynecology
R RomeroM D Mitchell
American Journal of Obstetrics and Gynecology
Y TanakaI Miyakawa
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Chan-Wook ParkJong Kwan Jun
© 2022 Meta ULC. All rights reserved