PMID: 9540950Apr 16, 1998Paper

Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis

Obstetrics and Gynecology
C Y SpongJ C Pezzullo

Abstract

To measure angiogenin, a potent inducer of neovascularization and interleukin-6, as an indicator of acute inflammation, in second-trimester amniotic fluid of patients with elevated maternal serum hCG. In this case-control study, 20 patients with elevated maternal serum hCG (at least 2.0 multiples of median) at triple screen were matched 2:1 with controls on the basis of year of amniocentesis, parity, and race. Inclusion criteria were 1) singleton gestation, 2) no evidence of anomalies, and 3) genetic amniocentesis. Amniotic fluid was immunoassayed for angiogenin and interleukin-6. The immunoassay sensitivity for angiogenin was 0.026 ng/mL, interassay coefficient of variation 4.6%, and intra-assay coefficient of variation 2.9%. For interleukin-6, the immunoassay sensitivity was 2.37 pg/mL, interassay coefficient of variation 2.7%, and intra-assay coefficient of variation 1.9%. Angiogenin and interleukin-6 values were normalized by using natural log transformation for statistical analysis. Statistical analysis included analysis of variance and stepwise regression, with P < .05 significant. After correcting (by multivariate regression) for gestational age at sampling and nulliparity, amniotic fluid angiogenin levels were significa...Continue Reading

References

May 1, 1990·The Journal of Clinical Investigation·R RomeroP B Sehgal
Oct 1, 1994·American Journal of Obstetrics and Gynecology·K D WenstromM B DuBard
Aug 1, 1996·Journal of Cellular Physiology·E AlsatD Evain-Brion

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Citations

Jul 30, 2011·Prenatal Diagnosis·Ahmet DemirNamik Demir
Aug 25, 2010·European Journal of Clinical Investigation·Eleonora SalvoliniRoberto Di Primio
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Alessandro Ghidini, Carolyn M Salafia
Apr 25, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·A L TranquilliG G Garzetti
Nov 23, 2006·Medical Hypotheses·Rosa M MichelOscar Arrieta

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