PMID: 2496111May 1, 1989Paper

Elevated serine catabolism is associated with the heat shock response in Escherichia coli

Journal of Bacteriology
R G Matthews, F C Neidhardt

Abstract

The biochemical events associated with the heat shock response are not well understood in any organism, nor have the signals that initiate the induction of heat shock protein synthesis been identified. In this work, we demonstrate that the rate of serine catabolism of Escherichia coli cells grown in glucose minimal medium supplemented with serine is elevated three- to sevenfold when the growth temperature is shifted from 37 to 44 degrees C. Elevations in growth temperature and mutations or treatments that lead to elevated basal rates of serine catabolism at 37 degrees C result in the excretion into the culture medium of acetate derived from exogenous serine. Increases in the basal level of serine catabolism at 37 degrees C do not per se induce a heat shock response but are associated with abnormalities in the pattern of induction of heat shock polypeptides following a temperature shift. We postulate that the events responsible for or resulting from the elevation in serine catabolism associated with a shift-up in temperature modulate the induction of 3 of the 17 heat shock polypeptides identified in E. coli. These observations suggest that heat shock diverts serine away from the production of glycine and C1 units, which are requ...Continue Reading

References

Apr 1, 1977·Journal of Bacteriology·B L WannerF C Neidhardt
Nov 7, 1977·Biochemical and Biophysical Research Communications·M De Felice, M Levinthal
Apr 5, 1976·Biochemical and Biophysical Research Communications·M Uzan, A Danchin
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R M BlumenthalS Pedersen
Jan 1, 1988·Annual Review of Biochemistry·L Gold
Aug 1, 1987·Genes & Development·R A VanBogelenF C Neidhardt
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M C GanozaR M Green
Nov 20, 1985·Journal of Molecular Biology·A D GrossmanC A Gross
Dec 1, 1972·Journal of Bacteriology·D Patterson, D Gillespie
Jul 1, 1973·Journal of Bacteriology·R C GreeneE H Coch
Apr 1, 1974·Journal of Bacteriology·S Isenberg, E B Newman
Sep 1, 1974·Journal of Bacteriology·F C NeidhardtD F Smith
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Jan 1, 1984·Annual Review of Genetics·F C NeidhardtV Vaughn
Apr 1, 1981·Journal of Bacteriology·I N HirshfieldF C Neidhardt
Dec 1, 1955·Journal of Bacteriology·A B PARDEE, L S PRESTIDGE

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Citations

Dec 1, 2004·EcoSal Plus·George V Stauffer
May 1, 1992·Journal of Bacteriology·R LinE B Newman
Nov 1, 2005·EcoSal Plus·Larry Reitzer
Jul 1, 1991·Journal of Bacteriology·C L SquiresC Squires

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