Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
George N IoannouSum P Lee

Abstract

In the United States, elevated serum alanine aminotransferase (ALT) activity in the absence of viral hepatitis or excessive alcohol consumption is most commonly attributed to nonalcoholic fatty liver disease (NAFLD). NAFLD is related to predictors of coronary heart disease (CHD) such as insulin resistance and central obesity. We examined the association between elevated serum ALT activity and the 10-year risk of CHD as estimated using the Framingham risk score (FRS). We performed a cross-sectional analysis comparing participants in the Third National Health and Nutrition Examination Survey with normal and elevated ALT activity (>43 IU/L), examining the mean levels of FRS. Among participants without viral hepatitis or excessive alcohol consumption, those with elevated ALT activity (n=267) had a higher FRS than those with normal ALT activity (n=7259), both among men (mean difference in FRS 0.25, 95% CI 0.07-0.4; hazard ratio for CHD 1.28, 95% CI 1.07-1.5) and women (mean difference in FRS 0.76, 95% CI 0.4-1.1; hazard ratio for CHD 2.14, 95% CI 1.5-3.0). The ALT threshold for increased risk of CHD was higher in men (>43 IU/L) than in women (>30 IU/L). Elevated ALT activity was not associated with higher FRS among nonobese particip...Continue Reading

References

Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R Wanless, J S Lentz
Sep 1, 1974·Journal of Chronic Diseases·T GordonJ Schiffman
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeckerG Jensen
May 29, 1998·Circulation·P W WilsonW B Kannel
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Nov 24, 1999·The American Journal of Medicine·G MarchesiniN Melchionda
Jun 2, 2000·Gastroenterology·V RatziuT Poynard
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gianfranco PaganoMario Rizzetto
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shivakumar ChitturiJacob George
Jan 4, 2003·Gastroenterology·Jeanne M Clark, Anna Mae Diehl
Jun 18, 2003·The American Journal of Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Jun 28, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola VillanovaGiulio Marchesini
Jul 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David D McPherson
Jan 13, 2006·The American Journal of Gastroenterology·George N IoannouSum P Lee

❮ Previous
Next ❯

Citations

Jun 11, 2009·Intensive Care Medicine·S J ThomsonT M Rahman
Jun 6, 2007·Current Diabetes Reports·Roger K SchindhelmRobert J Heine
Apr 18, 2008·Current Gastroenterology Reports·Mouen A KhashabNaga Chalasani
Jan 27, 2009·Current Gastroenterology Reports·Vijay Laxmi MisraNaga Chalasani
Apr 13, 2013·Journal of Physiology and Biochemistry·Amr M Abbas, Hussein F Sakr
Nov 25, 2011·Metabolic Syndrome and Related Disorders·Yasar ColakIlyas Tuncer
Mar 13, 2012·European Heart Journal·Lokpal S BhatiaChristopher D Byrne
Dec 14, 2011·International Journal of Epidemiology·Giulio Marchesini, Giovanni Targher
Feb 3, 2007·Current Opinion in Gastroenterology·Brent A Neuschwander-Tetri
Feb 21, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Phyllis C TienUNKNOWN Study of Fat Redistribution and Metabolic Change in HIV Infection Investigators
Jun 23, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sean W P KoppeRichard M Green
Mar 22, 2008·Pediatric Research·Lucia PacificoClaudio Chiesa
Nov 26, 2008·World Journal of Gastroenterology : WJG·Yu-Cheng LinChao-Jen Chen
Jun 18, 2010·Pediatric Health·Nicole J BarshopJoel E Lavine
Jun 1, 2013·Experimental Gerontology·Zhongli WangEn Yin Lai
Sep 4, 2012·Clinical Rheumatology·J C van DenderenM T Nurmohamed
Oct 23, 2013·Nature Reviews. Cardiology·Farzad MasoudkabirMark J Eisenberg
Oct 6, 2009·Journal of Gastroenterology·Claudio CaralloFrancesco Scopelliti
May 15, 2010·Journal of Hypertension·Paolo SalviPaolo Pazzi
May 14, 2010·Digestive Diseases and Sciences·Sombat TreeprasertsukKeith D Lindor
Dec 22, 2006·Expert Opinion on Drug Safety·Khalid A OsmanMohamed H Ahmed
Jun 2, 2011·The American Journal of the Medical Sciences·Lorenzo MaroniAchille Venco
Jan 8, 2016·Journal of Hepatology·Philip N OkaforJayant A Talwalkar
Sep 3, 2013·Journal of Clinical Anesthesia·Edward GologorskyKyota Fukazawa
Feb 20, 2014·Obesity Research & Clinical Practice·Leticia Elizondo-MontemayorUbaldo Martínez
Jul 25, 2012·Clinics in Liver Disease·Tommy Pacana, Michael Fuchs
Nov 16, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Shefali Agrawal, Cherag Daruwala
Jul 28, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A Gastaldelli, G Basta
Nov 12, 2009·Regulatory Toxicology and Pharmacology : RTP·Josef S OzerShashi K Ramaiah
Jun 30, 2009·Medicina clínica·Diego Moreno Sánchez
May 16, 2009·Clinics in Liver Disease·Jacqueline G O'LearyLawrence S Friedman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.