Elevated Serum Brain-Derived Neurotrophic Factor (BDNF) but not BDNF Gene Val66Met Polymorphism Is Associated with Autism Spectrum Disorders

Molecular Neurobiology
Wei-Dong MengQiang Liu

Abstract

The aim of our study was to illuminate the potential role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder (ASD). We measured the circulating levels of BDNF in serum and BDNF gene (Val66Met) polymorphisms, in which two indicators were then compared between ASD and normal controls. A total of 82 drug-naïve ASD children and 82 age- and gender-matched normal controls were enrolled in the study. Their serum BDNF levels were detected by the ELISA. BDNF Val66Met polymorphism genotyping was conducted as according to the laboratory's standard protocol in laboratory. The ASD severity assessment was mainly determined by the score of the Childhood Autism Rating Scale (CARS). ELISA assay showed that the mean serum BDNF level of children with ASD was significantly (P < 0.0001) higher than that of the control cases (17.75 ± 5.43 vs. 11.49 ± 2.85 ng/ml; t = 9.236). Besides, the serum BDNF levels and CARS scores (P < 0.0001) were positively related. And, the BDNF genotyping results showed that there was no difference between the ASD cases and the control. Among the children with ASD, the mean serum BDNF level of Met/Met group was lower than other groups. According to the ROC curve generated from our clinical data, the op...Continue Reading

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Citations

Aug 10, 2016·Cellular and Molecular Neurobiology·Raluca ArmeanuBernard Crespi
Feb 1, 2017·Journal of Autism and Developmental Disorders·Amene Saghazadeh, Nima Rezaei
Jul 30, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Esra DemirciSefer Kumandas
Apr 20, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lixuan WangKuo Li
Oct 25, 2020·International Journal of Molecular Sciences·Luca Colucci-D'AmatoFloriana Volpicelli
Oct 17, 2020·Scientific Reports·Alexandre Garcia BarbosaClaudia B Pratesi
Jul 23, 2021·Autism Research : Official Journal of the International Society for Autism Research·Hasan BozkurtSerkan Şahin

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Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS

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