Elevated serum creatinine levels associated with fenofibrate therapy

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Charles R McQuadeAmy Barton Pai

Abstract

The case of a patient who developed clinically relevant increases in serum creatinine (SCr) levels while receiving fenofibrate therapy is reported. Fenofibrate therapy was initiated for a 60-year old Hispanic man with stage 4 chronic kidney disease (CKD) for the treatment of hypertriglyceridemia. Two weeks after taking 48 mg of fenofibrate daily, the patient's SCr and blood urea nitrogen concentrations increased from 3.0 and 25 mg/dL, respectively, to 3.5 and 30 mg/dL, respectively. His estimated glomerular filtration rate (eGFR) had decreased from 24.8 to 17.9 mL/min/1.73 m(2). One month after initiating fenofibrate, his SCr concentration had increased to 3.7 mg/dL, a 32% increase from baseline. Because of persistently high triglyceride concentrations (e.g., 402 mg/dL), the fenofibrate dosage was increased to 145 mg daily. The patient's SCr concentration rose to 4.7 mg/dL (a 62% increase from baseline), and his eGFR was calculated as 13 mL/min/1.73 m(2). The patient was referred by the nephrology service for vascular-access placement in preparation for hemodialysis. Four days after discontinuation of fenofibrate, the patient's SCr concentration dropped to 3.3 mg/dL and returned to baseline approximately six weeks later, with a...Continue Reading

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Citations

Apr 27, 2011·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Christine B BrunoParya Saberi
Sep 30, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarSokkalingam A Dhanaraj
Jan 31, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarNanjaian Mahadevan
Jan 24, 2012·Journal of Clinical Lipidology·Rebecca L AttridgeChristopher R Frei
Dec 3, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Bernard Lawrence MariniDavid G Frame
Nov 9, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Carmen R Cobelo CasasJesús Calviño Varela
Aug 5, 2017·Korean journal of family medicine·Sungjong KimJungun Lee
Jul 4, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rebecca L AttridgeWilliam D Linn
Sep 5, 2008·Current Opinion in Lipidology·Ngoc-Anh Le

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