PMID: 7137Apr 1, 1976

Elevated serum gamma-glutamyl-transferase (transpeptidase) and histological liver damage in alcoholism

The American Journal of Gastroenterology
A WuA J Levi


In 66 alcoholic patients, serum gamma-glutamyl-transferase (transpeptidase) (GGTP) activity was studied in relationship to other biochemical liver function tests and histological liver damage. Elevated serum GGTP activity was the single most common biochemical abnormality (74%) and, when present was accompanied by histological abnormalities in all but one case. In seven patients, including two with alcoholic cirrhosis, this was the only biochemical abnormality. The mean serum GGTP was highest in the cirrhotic group. There was some correlation between serum GGTP activity and the degree of histological hepato-cellular necrosis. The values showed a wide scatter, however, and 12 patients had normal serum GGTP activity when histological damage was present. While elevated serum GGTP levels in alcoholism may be partly related to structural liver damage, other mechanisms, such as hepatic microsomal enzyme induction or alcoholic pancreatic damage, may also play a role.

Related Concepts

Alcohol Abuse
Alkaline Phosphatase
SGOT - Glutamate oxaloacetate transaminase
Bilirubin, (4E,15E)-Isomer
Gamma-glutamyl transferase
Fibrosis, Liver
Liver Dysfunction
Liver Function Tests

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.