Elevated serum homocysteine levels for gouty patients

Clinical Rheumatology
Tien-Tsai ChengShue-Fen Luo

Abstract

Our objective was to analyze serum total homocysteine (tHcy) levels for gouty patients and to study whether there are any level changes following treatment with allopurinol. We enrolled 90 male participants including patients with primary gout (n=51) and community-based healthy controls (n=39). Fasting tHcy levels were determined for all subjects and repeat measurements performed for 29 patients following treatment with allopurinol. The results revealed that gouty patients exhibited significantly greater serum tHcy levels (12.10+/-3.19 micromol/l) than healthy controls did (9.96+/-2.16 micromol/l) (p=0.0003), although there was no obvious difference between the pre-allopurinol treatment group (12.54+/-3.31 micromol/l) and its post-treatment analogue (11.90+/-4.68 micromol/l) (n=29, p=0.33). Elevated serum levels of tHcy were noted for this cohort of male gouty patients as compared to healthy controls, and these tHcy levels did not appear to change substantially following treatment with allopurinol. Although the pathogenesis of hyperhomocysteinemia for gouty patients still remains somewhat obscure, this study suggests that tHcy levels cannot be effectively modulated by treatment with allopurinol.

References

Apr 1, 1977·Arthritis and Rheumatism·S L WallaceT F Yü
Sep 1, 1975·Atherosclerosis·K S McCully, R B Wilson
Mar 1, 1980·The American Journal of Medicine·W J Fessel
Jan 1, 1994·The Journal of Clinical Endocrinology and Metabolism·H Vuorinen-Markkola, H Yki-Järvinen
Jan 1, 1993·The American Journal of Clinical Nutrition·J B UbbinkP J Becker
Apr 1, 1997·Arthritis and Rheumatism·R RoubenoffI H Rosenberg
Dec 16, 1998·Annals of the Rheumatic Diseases·B Emmerson
Sep 4, 1999·Annals of Internal Medicine·J W EikelboomS Yusuf
Jul 27, 2001·Diabetes Care·J B MeigsUNKNOWN Framingham Offspring Study
Apr 12, 2003·The American Journal of Medicine·En-Pei I ChiangRonenn Roubenoff

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Citations

Mar 15, 2013·Iranian Red Crescent Medical Journal·Mohammadali NazariniaZeinab Khademalhosseini
Jul 13, 2011·Cell Biochemistry and Biophysics·Xing-Liang JiangJuan Du
Nov 14, 2014·The Cochrane Database of Systematic Reviews·Alison S R KyddClaire Bombardier
Oct 6, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takao HashimotoHiroshi Hasegawa
Jun 30, 2018·Current Rheumatology Reviews·Mohammadali NazariniaMesbah Shams

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