PMID: 6164710May 1, 1981Paper

Elevated serum immunoglobulin E in bronchial carcinoma: its relation to the histology and prognosis of the cancer

The Journal of Allergy and Clinical Immunology
R HällgrenO Zetterström

Abstract

Total IgE and specific IgE antibodies against six common allergens were measured in the sera of 217 unselected patients with bronchial carcinoma. Their median total IgE level was significantly increased as compared to the median levels found in two control populations consisting of 246 individuals representing the adult general population and 143 patients with benign pulmonary disorders. The frequency of serological atopy, i.e., the presence of specific IgE antibodies, was also significantly increased in the cancer population as compared to the controls. In contrast, the incidence of possible clinical atopy was about five times higher in the general population than in the cancer group. Patients with bronchial carcinoma typed as adenocarcinoma had the best prognosis and also had nonelevated IgE levels in contrast to patients with bronchial carcinoma typed as squamous cell carcinoma, small or large cell carcinoma. The favourable prognosis with nonelevated IgE levels also was demonstrated in patients with squamous cell carcinoma. It is suggested that the elevated IgE levels in bronchial carcinoma reflect impaired cellular immunity.

Citations

Jun 10, 2010·Cancer Causes & Control : CCC·Mieke Van HemelrijckLars Holmberg
Nov 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Patricia TennisChantal Dolan
Jan 6, 2006·International Journal of Cancer. Journal International Du Cancer·Michelle C TurnerParviz Ghadirian
Jan 1, 1983·Acta Medica Scandinavica·R Hällgren, L Lundin
Jun 15, 1984·International Journal of Cancer. Journal International Du Cancer·N B PidcockI el-Sebai
Jan 1, 1982·Acta Medica Scandinavica·R HällgrenK Hiesche

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