PMID: 11914142Mar 27, 2002Paper

Elevated serum immunoglobulin E to Cryptomeria japonica pollen in rats exposed to diesel exhaust during fetal and neonatal periods

BMC Pregnancy and Childbirth
Nobue Watanabe, Masanobu Ohsawa

Abstract

BACKGROUND: The possible participation of diesel exhaust inhalation during the fetal period in the elevation of IgE against pollen in postnatal life was investigated. METHOD: The experiment was conducted using rat pups. Group I; exposed to clean air (Control). Group 2, 3; exposed to total or filtered diesel exhaust during the fetal period (Total-C-C, Filtered-C-C). Group 4, 5; exposed to total or filtered diesel exhaust during the suckling period (C-Total-C, C-Filtered-C). Group 6,7; exposed to total or filtered diesel exhaust during the weaning period (C-C-Total, C-C-Filtered). Total diesel engine exhaust contained 1.73 mg/m3 particulate matter and 0.79 ppm nitrogen dioxide; filtered exhaust contained the same gases as the total exhaust without particulate matter. Intraperitoneal injection of 5 mg crude cedar pollen was performed at 2-week intervals from the 49th day after birth. RESULTS: The mean IgE titers measured by the P-K reaction in the Control, Total-C-C, Filtered-C-C, C-Total-C, C-Filtered-C, C-C-Total and C-C-Filtered were 64.0 ± 2.7, 469.5 ± 1.6, 332.0 ± 1.7, 380.4 ± 1.7, 394.8 ± 1.7, 115.9 ± 1.3 and 57.0 ± 2.8 respectively after the fourth immuni...Continue Reading

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Citations

Mar 16, 2013·Autism Research : Official Journal of the International Society for Autism Research·Keerthi Thirtamara RajamaniHoward Gu
Sep 19, 2008·Inhalation Toxicology·M D ReedJ A Swenberg
Jan 29, 2016·TheScientificWorldJournal·Hélène SénéchalJean-Pierre Sutra
Jun 2, 2012·The Clinical Respiratory Journal·Berit Hvass ChristensenVivi Schlünssen

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