Elevated Serum Interleukin-34 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity.

Scientific Reports
Huan Huan XieJ Lu

Abstract

We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria. The SLE disease activity was scored using the SLE Disease Activity Index (SLEDAI). Among the 110 SLE cases, IL-34 could be detected in 79 cases (71.8%). IL-34 was barely detected in the control group. The serum level of IL-34 was significantly higher in the SLE group. No change was observed in the serum IL-34 concentration in the SLE patients regardless of LN status. Correlations were observed between the serum IL-34 level and the disease activity parameters. The SLE patients with detectable IL-34 levels had higher SLEDAI and IgG concentrations and lower C3 and Hb levels than patients with undetectable IL-34 levels. Therefore, IL-34 could be...Continue Reading

References

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Citations

Aug 2, 2018·Journal of Leukocyte Biology·Muhammad BaghdadiKen-Ichiro Seino
Oct 18, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jovani Catalan-DibeneAlbert Zlotnik
Jan 10, 2019·Journal of the American Society of Nephrology : JASN·Yukihiro WadaVicki R Kelley
Apr 24, 2019·Immunological Investigations·Miaomiao LiJun Li
Jun 8, 2019·Journal of Cellular Physiology·Wang-Dong XuLin-Chong Su
Jan 16, 2020·The Journal of Experimental Medicine·Iva LeliosMelanie Greter
Nov 28, 2019·Autoimmunity·Farhana Muhammad YusoffNorhanani Mohd Redzwan
Dec 12, 2019·International Journal of Rheumatic Diseases·Yanmei LiuHui Shen
Jan 8, 2020·Clinical Rheumatology·Hanaa Samy El-BannaSouzan Ezzat Gado
Apr 3, 2020·Lupus·Asmaa Sm Abdel-RehimMarwa M Shakweer
Feb 19, 2021·Journal of Leukocyte Biology·Antoine FreuchetIgnacio Anegon
Apr 24, 2021·Veterinary Dermatology·Rosanna Marsella

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Methods Mentioned

BETA
ESR
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
GraphPad

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