Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-gamma gene.

Clinical and Experimental Immunology
N Martínez-PomarN Matamoros

Abstract

Common variable immunodeficiency disease (CVID) is a heterogeneous syndrome characterized by low immunoglobulin serum levels and recurrent bacterial infections. Several studies suggest that CVID patients have a polarized immune response towards a T helper type 1 phenotype (TH1). However, the factors causing the TH1 polarization remain to be determined in this disease. In the present study, serum interleukin (IL)-12, interferon (IFN)-gamma levels and the IL-12p40 and IFN-gamma gene were studied in CVID patients. Furthermore, we evaluate dendritic cells (DCs) compartment, myeloid dendritic cells (mDCs) and plasmocytoid dendritic cells (pDCs), which help to differentiate naive T cells preferentially into TH1 and TH2, respectively. The serum IL-12p40 subunit levels were increased significantly in CVID patients compared to healthy controls. We examined whether these elevated serum IL-12p40 levels are associated with IFN-gamma or IL-12p40 gene polymorphisms, or with new mutations in the IL-12p40 promoter gene. In our hands, no new mutations were found and gene polymorphisms frequencies in CVID patients were similar to the control population. In conclusion, the elevated serum levels of IL-12p40 found in our CVID patients were not rela...Continue Reading

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·U GublerP C Familletti
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A S SternR Chizzonite
Apr 1, 1994·Clinical and Experimental Immunology·A J StaggJ Farrant
Jan 1, 1996·The Journal of Experimental Medicine·X MaG Trinchieri
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Jun 6, 1998·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J L BidwellG J Laundy
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Mar 9, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·V PravicaI V Hutchinson
May 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J L BidwellG J Laundy
Aug 7, 1999·Immunology Letters·M L Kapsenberg, P Kalinski
Oct 3, 1999·European Journal of Immunology·S P RobinsonC D Reid
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·R CambroneroJ Farrant
May 4, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kazunaga AgematsuHans D Ochs
Nov 17, 2004·Clinical and Experimental Immunology·T H Scott-TaylorA D B Webster
Feb 5, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Cristina IbáñezJosé-Bruno Montoro

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Citations

Sep 24, 2014·Journal of Clinical Immunology·Zdenek HelJiri Litzman
Feb 13, 2009·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Tomohiro ShimizuMasaya Mukai
Dec 15, 2015·Expert Review of Clinical Immunology·Laleh SharifiAsghar Aghamohammadi
Nov 14, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Francisco A BonillaKlaus Warnatz
Aug 30, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Martin KuntzKlaus Warnatz
Sep 6, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sander van AssenMarc Bijl
Dec 19, 2006·Allergologia et immunopathologia·A Blanco-QuirósE Arranz-Sanz
Oct 22, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Børre FevangStig S Frøland
Feb 26, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patrick F K YongMohammad A A Ibrahim
Oct 12, 2015·Immunology and Allergy Clinics of North America·Jordan K Abbott, Erwin W Gelfand
Apr 7, 2009·British Journal of Haematology·Helen Chapel, Charlotte Cunningham-Rundles
Jun 24, 2009·Memórias do Instituto Oswaldo Cruz·Maíra Cavalcanti de AlbuquerqueMaria Regina Reis Amendoeira
Oct 17, 2013·Expert Review of Clinical Immunology·Yashwant Kumar, Alka Bhatia
Dec 20, 2018·Immunological Reviews·Charlotte Cunningham-Rundles
Feb 23, 2020·Frontiers in Immunology·Corentin Le Saos-PatrinosDorothée Duluc
Feb 23, 2021·Frontiers in Immunology·Erik M MatsonPaul J Maglione
Mar 16, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Theodore K LeePaul J Maglione
Jun 20, 2021·The Journal of Allergy and Clinical Immunology·Miranda L AbyaziPaul J Maglione

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