Elevated serum leptin, adiponectin and leptin to adiponectin ratio is associated with chronic kidney disease in asian adults

PloS One
Cynthia Ciwei LimC Sabanayagam

Abstract

Adiponectin and leptin, two of the key cytokines secreted by adipocytes, have been shown to be associated with cardiovascular disease. However, the association of these adipocytokines with chronic kidney disease (CKD) is not clear. We examined the association of serum adiponectin, leptin levels and leptin to adiponectin ratio (LAR) with CKD in a population-based sample of Asian adults. We conducted a case-control study (450 CKD cases and 920 controls matched for age, sex and ethnicity) involving Chinese and Indian adults aged 40-80 years who participated in the Singapore Epidemiology of Eye Diseases Study (2007-2011). CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73m2 from serum creatinine. Serum adiponectin and leptin levels were measured using commercially available ELISA. Odds ratio of CKD associated with elevated adiponectin and leptin levels were estimated using logistic regression models adjusted for age, gender, ethnicity, education, smoking, body mass index, diabetes, blood pressure, total and HDL cholesterol. CKD cases had higher levels of leptin (mean [SD] 9.7 [11.5] vs.16.9 [20.2] ng/mL, p<0.0001) and adiponectin (10.4 [7.4] vs. 9.2 [4.2], p = 0.001) compared to controls. In multi-variable m...Continue Reading

References

Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Jul 15, 1997·The Journal of Clinical Investigation·W G HaynesW I Sivitz
Oct 10, 1998·Kidney International·L NordforsP Stenvinkel
Oct 27, 1999·Metabolism: Clinical and Experimental·B Fruehwald-SchultesA Peters
Jul 10, 2002·Hypertension·Carmine ZoccaliUNKNOWN CREED investigators
Jan 28, 2003·Lancet·Joachim SprangerAndreas F H Pfeiffer
Aug 28, 2003·Diabetes, Obesity & Metabolism·B I ShandP M George
Apr 14, 2004·Clinical Nephrology·V MenonM J Sarnak
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Helen C LookerRobert L Hanson
Dec 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fitsum Guebre-EgziabherDenis Fouque
Mar 4, 2005·Journal of the American Society of Nephrology : JASN·Bjoern BeckerUNKNOWN MMKD Study Group
Mar 31, 2005·Metabolism: Clinical and Experimental·Viswanathan MohanVenkatesan Radha
May 28, 2005·Diabetes Care·Markku SaraheimoUNKNOWN FinnDiane study group
Jul 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M P-S LeeG Sweeney
Oct 13, 2005·The Journal of Clinical Endocrinology and Metabolism·Casper G SchalkwijkUNKNOWN EURODIAB Prospective Complications Study Group
Oct 19, 2006·Advances in Chronic Kidney Disease·Guido LastraJames R Sowers
Mar 27, 2007·Cytokine·Subhashini YaturuSushil K Jain
Sep 8, 2007·Stroke; a Journal of Cerebral Circulation·Giuseppe Danilo NorataAlberico L Catapano
Apr 24, 2008·The Journal of Clinical Investigation·Kumar SharmaBarry J Goldstein
Apr 11, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G D NorataA L Catapano
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jun 6, 2012·International Journal of Nephrology·Anoop ShankarPaul Muntner
Jun 23, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Boon Wee TeoEvan J C Lee
Jul 24, 2012·European Journal of Internal Medicine·Paul J W H KappelleBruce H R Wolffenbuttel
Aug 3, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Jung Tak ParkShin-Wook Kang
Oct 17, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ying-Chieh LiaoWayne H-H Sheu
Nov 28, 2012·Clinical and Experimental Nephrology·Kunitoshi IsekiTsuyoshi Watanabe
Jan 4, 2013·Kidney International·Maria P Martinez CantarinBonita Falkner
Apr 12, 2013·Journal of Atherosclerosis and Thrombosis·Ayaka TsuboiKeisuke Fukuo
Oct 12, 2013·PloS One·Katherine T MillsJing Chen

❮ Previous
Next ❯

Citations

Feb 14, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Styliani BouzianaApostolos Ι Ηatzitolios
Nov 6, 2017·Clinical and Experimental Nephrology·Hirokazu HondaAkira Hishida
Dec 5, 2017·Nature Reviews. Nephrology·Qingzhang Zhu, Philipp E Scherer
Dec 19, 2017·Global Heart·Jeffrey I MechanickW Timothy Garvey
Sep 2, 2019·Sleep & Breathing = Schlaf & Atmung·Dong-Dong ChenXiao-Fang Chen
Feb 18, 2020·Aging·Huan JingJun Zhou
Aug 4, 2020·American Journal of Physiology. Renal Physiology·Yifan HuaThomas Remer
Apr 13, 2019·International Journal of Molecular Sciences·Yaeni Kim, Cheol Whee Park
Sep 14, 2018·Experimental and Therapeutic Medicine·Zhang DaiZhongying Zhang
Nov 6, 2018·World Journal of Hepatology·Wanvisa UdomsinprasertYong Poovorawan
Jan 20, 2020·International Urology and Nephrology·Joanna JagiełaJacek Rysz
May 1, 2021·International Journal of Molecular Sciences·Justyna KorczynskaTomasz Sledzinski
Jun 23, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Fathimah S SigitRenée de Mutsert

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SAS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

Investigative Ophthalmology & Visual Science
Sudarshan SeshasaiC Sabanayagam
International Journal of Endocrinology
Pavani Bandaru, A Shankar
© 2021 Meta ULC. All rights reserved