Elevated Serum Levels of CXC Chemokine Ligand-12 Are Associated with Unfavorable Functional Outcome and Mortality at 6-Month Follow-up in Chinese Patients with Acute Ischemic Stroke

Molecular Neurobiology
Xuan ChengChuan-Jie Wu

Abstract

The aim of this study was to examine whether the circulating CXC chemokine ligand-12 (CXCL12) level can predict a 6-month outcome in Chinese patients with acute ischemic stroke (AIS). In a prospective study, CXCL12 levels were measured on admission in the serum of 304 consecutive patients with AIS. The prognostic value of CXCL12 to predict the functional outcome and mortality within 1 year was compared with the National Institutes of Health Stroke Scale score and with other known outcome predictors. A receiver operating characteristic (ROC) curve was used to evaluate the accuracy of serum CXCL12 in predicting functional outcome and mortality. Patients with an unfavorable outcome and non-survivors had significantly increased CXCL12 levels on admission (P < 0.0001 and P < 0.0001). Multivariate logistic regression analysis adjusted for common risk factors showed that CXCL12 (≥12.4 ng/mL; third quartile) was an independent predictor of functional outcome (odds ratio [OR] = 8.81; 95 % confidence interval [CI] 4.92-24.79) and mortality (OR = 10.15; 95 %CI 2.44-27.98). The area under the receiver operating characteristic curve of CXCL12 was 0.84 (95 % CI 0.76-0.92) for functional outcome and 0.87 (95 % CI 0.80-0.93) for mortality. Cir...Continue Reading

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Citations

May 7, 2016·Expert Review of Neurotherapeutics·Hung NguyenCesario V Borlongan
Jun 3, 2016·Frontiers in Molecular Neuroscience·Amanda J Craig, Gary D Housley
May 21, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jia ShenJian-Bo Gao
Feb 8, 2018·Journal of Internal Medicine·A SimatsJ Montaner
Nov 4, 2021·World Neurosurgery·Sauson SoldozyM Yashar S Kalani

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
ROCR

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