Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study

SAGE Open Medicine
Md Rabiul IslamAbul Hasnat

Abstract

Major depressive disorder is diagnosed on the basis of patient's self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this. Mood-regulating pathways are affected by oxidative injury to lipids and cortisol is released into the blood due to stimulation of corticotrophin receptors in the adrenal cortex. Here, we aimed to determine serum levels of malondialdehyde and cortisol in major depressive disorder patients and controls. We collected blood samples from 247 major depressive disorder patients and 248 controls. Serum levels of malondialdehyde and cortisol were measured by ultraviolet spectrophotometry and enzyme-linked immunosorbent assay kit, respectively. We found malondialdehyde levels were significantly higher in patients than controls, with mean ± standard deviation at 4.49 ± 1.37 and 2.87 ± 0.82 µmol/L, respectively, p < 0.001. Cortisol levels were also found significantly higher in patients than controls, with mean ± SD at 19.22 ± 1.64 and 17.37 ± 1.34 µg/dL, respectively, p < 0.001. Significant negative correlation was observed between serum levels of malondialdehyde and cortisol in patients (r =-0.170, p = 0.021). Receiver operating...Continue Reading

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Citations

May 14, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dawid SzczepankiewiczAleksandra Szczepankiewicz
May 1, 2020·Oxidative Medicine and Cellular Longevity·Ana Paula Vargas VisentinMirian Salvador
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Feb 5, 2021·Journal of Clinical Medicine·Sylwia ChojnowskaNapoleon Waszkiewicz
Dec 8, 2020·SAGE Open Medicine·Sohel DariaMd Rabiul Islam
Jan 5, 2022·Journal of Basic and Clinical Physiology and Pharmacology·Maliha Afrin PromaMd Rabiul Islam

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Methods Mentioned

BETA
MDA
enzyme-linked immunosorbent assay
ELISA
pharmacotherapy

Software Mentioned

SPSS

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