PMID: 20110624Jan 30, 2010Paper

Elevated serum levels of S100 calcium binding protein A8 (S100A8) reflect disease severity in canine atopic dermatitis

The Journal of Veterinary Medical Science
Tae-Ho ChungCheol-Yong Hwang

Abstract

A monoclonal antibody to canine S100 calcium binding protein A8 (S100A8) was developed to determine the association between S100A8 and the disease severity of canine atopic dermatitis. Serum S100A8 concentrations were studied in dogs with canine atopic dermatitis (n=213) and healthy dogs (n=213). Statistical correlations between these indices and atopic dermatitis activity were established, and dermatitis severity was assessed according to the CADESI score. Serum S100A8 concentrations were measured with an enzyme-linked immunosorbent assay (ELISA). S100A8 serum levels were significantly higher in canine atopic dermatitis patients than in healthy dogs. A strong positive correlation was identified between S100A8 levels and canine atopic dermatitis patients. Our findings suggested that S100A8 is actively involved in the pathogenesis and clinical picture of canine atopic dermatitis.

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Citations

Apr 23, 2011·BMC Genetics·Cary A SalzmannNatasha J Olby
Mar 27, 2015·Veterinary Dermatology·Cherie M Pucheu-HastonMelissa N C Eisenschenk
Nov 15, 2020·The Veterinary Clinics of North America. Small Animal Practice·Juan Hernandez, Julien Rodolphe Samuel Dandrieux

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