Elevated serum levels of soluble interleukin-4 receptor in osteoarthritis

Osteoarthritis and Cartilage
T SilvestriR Meliconi

Abstract

To test the importance of the interleukin-4 (IL-4)/IL-4 receptor (IL-4R) system in osteoarthritis (OA) we evaluated soluble IL-4R (sIL-4R) levels in sera of patients with different forms of OA and healthy individuals. We recruited: 141 patients with hand OA, 70 with nodal and 71 with erosive hand OA; 64 patients undergoing total joint replacement, 34 with hip and 30 with knee OA; and 38 ethnically and geographically age-matched healthy individuals [normal controls (NC)]. Serum sIL-4R concentration was found to be significantly higher in all OA patients than that in NC. When patients were divided into four subgroups (nodal, erosive, hip and knee OA) significant differences were present when comparing NC with each subgroup. This was true also when small-joint OA groups were compared with large-joint OA groups, the latter being associated with higher IL-4R levels. We found increased levels of sIL-4R in OA patients compared with healthy individuals. We speculate that this reduces availability of IL-4, and its effects on chondrocytes.

References

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Citations

May 31, 2014·Mediators of Inflammation·Piotr WojdasiewiczDariusz Szukiewicz
Jul 19, 2015·Cytokine·Sarah M McCormick, Nicola M Heller
Jan 28, 2015·Clinical Orthopaedics and Related Research·Jeffrey J NeppleJohn C Clohisy
Apr 29, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Thomas MabeyYong Poovorawan
Aug 12, 2019·Biomolecular Concepts·Akul MunjalSadanand Fulzele
Jan 4, 2020·Journal of Zhejiang University. Science. B·Dong ZhanSittisak Honsawek
Mar 20, 2020·Mediators of Inflammation·Yoke Yue Chow, Kok-Yong Chin
Mar 30, 2021·Mediators of Inflammation·Rajkamal KumavatSagarika Biswas
Jun 15, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ericka P von KaepplerWilliam H Robinson

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