Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis

The American Journal of Gastroenterology
Haq NawazGeorgios I Papachristou

Abstract

Hypertriglyceridemia (HTG) represents a major health problem with prevalence exceeding 30% in the U.S. The present study aims to assess the effect of elevated serum triglyceride (TG) levels on the severity of acute pancreatitis (AP). Prospectively enrolled AP patients were categorized into normal, mild, moderate, and severe/very severe categories based on their TG levels and compared in respect to demographics, comorbidities, and clinical outcomes. Multivariate analysis determined whether elevated TG levels were independently associated with persistent organ failure. Two hundred and one out of 400 AP patients had serum TGs measured within 72 h of presentation, of which 115 had normal TG levels and 86 HTG (20 mild, 41 moderate, and 25 severe/very severe). Patients with HTG were of younger age (44 vs. 52 years), predominantly male (65% vs. 45%), obese (57% vs. 34%), diabetic (38% vs. 17%), and developed more frequently persistent organ failure (40% vs. 17%) compared with those with normal TGs (P<0.02). The rate of persistent organ failure increased proportionally with HTG severity grades (17% when normal TGs, 30% in mild, 39% in moderate, and 48% in severe/very severe HTG, Ptrend<0.001). On multivariate analysis controlling for a...Continue Reading

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Citations

Jan 21, 2016·The American Journal of Gastroenterology·Emmanuel I González-MorenoHéctor J Maldonado-Garza
Mar 26, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rosalie A CarrNicholas J Zyromski
Jul 23, 2016·Canadian Journal of Gastroenterology & Hepatology·Hassan TariqSridhar Chilimuri
Jan 13, 2017·Scientific Reports·Yiyuan PanJieshou Li
Jun 26, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Congye WuJieshou Li
Sep 6, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·James M Falko
Feb 7, 2019·Digestive Diseases and Sciences·Mahya Faghih, Vikesh K Singh
Jun 6, 2019·Clinical and Translational Gastroenterology·David C Whitcomb, UNKNOWN North American Pancreatitis Study Group
Jul 7, 2017·Current Opinion in Gastroenterology·Bomi LeeAida Habtezion
Dec 4, 2019·BMJ : British Medical Journal·O Joe Hines, Stephen J Pandol
Dec 5, 2019·International Journal of Clinical Practice·Zhihua LuDonghai Wang
Dec 24, 2016·Journal of Clinical Gastroenterology·Ji Hye HuhKyong Joo Lee
Jul 19, 2017·Current Opinion in Gastroenterology·Biswajit KhatuaVijay P Singh
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Jul 19, 2016·Current Opinion in Gastroenterology·Anna S GukovskayaIlya Gukovsky
Jul 21, 2017·Journal of Intensive Care·Anis ChaariWilliam Francis Casey

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