Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects.

Journal of Zhejiang University. Science. B
Hang HuAndries J Smit

Abstract

This study was designed to evaluate the association between skin autofluorescence (AF), an indicator of advanced glycation end-products (AGEs), and foot ulcers in subjects with diabetes. In this study, 195 Chinese diabetic subjects were examined. Their feet were examined regardless of whether an ulcer was present or not. Skin AF was measured with an AGE reader. Demographic characteristics and blood data were recorded. The mean values of skin AF were 2.29 ± 0.47 for subjects without foot ulcers, and 2.80 ± 0.69 for those with foot ulcers, a significant difference (P<0.05). Skin AF was strongly correlated with age and duration of diabetes. After adjusting for these factors, multivariate logistic regression showed that skin AF was independently associated with foot ulcerations. Skin AF is independently associated with diabetic foot ulcerations. It might be a useful screening method for foot ulceration risk of diabetic patients.

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Citations

May 2, 2013·Diabetes Technology & Therapeutics·Julien VouillarmetCharles Thivolet
May 15, 2015·Scientific Reports·Muhammad S AhmadElaine Holmes
May 23, 2014·Diabetes/metabolism Research and Reviews·Hang HuChunmao Han
Jan 16, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kalina RajaobelinaVincent Rigalleau
May 29, 2016·Diabetes/metabolism Research and Reviews·K RajaobelinaV Rigalleau
Oct 28, 2017·The Journal of Vascular Access·Damian G McGroganNicholas G Inston
Jun 18, 2019·Journal of Diabetes Science and Technology·Malindu E FernandoJonathan Golledge
Jan 3, 2021·Journal of Diabetes and Its Complications·Saad RojuballyVincent Rigalleau
Feb 4, 2021·Endocrinology, Diabetes & Metabolism·Sophia RossbothWilli Oberaigner
Jan 12, 2021·Saudi Journal of Biological Sciences·Ali S AlqahtaniGeorge Q Li
Feb 25, 2021·BMC Endocrine Disorders·Stella PapachristouNikolaos Papanas
May 4, 2021·Wiener klinische Wochenschrift·Sophia RossbothWilli Oberaigner

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