Elevated soluble CD23 level indicates increased risk of B cell non-Hodgkin's lymphomas: evidence from a meta-analysis

Annals of Hematology
Yi-Shu HuangZheng-Tao Lv

Abstract

The aim of the present study was to determine whether circulating soluble CD23 (sCD23) was associated with B cells non-Hodgkin's lymphomas (B-NHL). PubMed, EMBASE, and ISI Web of Science were extensively searched without language restriction. Data was extracted in a standardized data collection sheet after two reviewers scanned studies independently. The association between sCD23 and NHL was indicated as odds ratio (OR) along with its related 95% confidence interval (95% CI). Meta-analysis was conducted via RevMan 5.3. A total of five studies, which included 964 B-NHL patients and 1243 matched controls without B-NHL, among which 257 were HIV-positive donors and 986 were general controls, were included in our study. Meta-analysis revealed a significant association between peripheral sCD23 level and B-NHL in HIV-positive samples (OR 1.66, 95% CI 1.25, 2.20; P = 0.0005) as well as the general population (OR 2.51; 95% CI 1.71, 3.86; P < 0.00001). Meta-analysis, stratified by sampling time prior to diagnosis, indicated potential HIV-NHL patients are 2.34-folds more likely to have higher blood sCD23 level, although this association is statistically meaningful only during 3-5 years prior to diagnosis (95% CI 1.27, 4.33). Subgroup anal...Continue Reading

References

Jan 1, 1991·Advances in Immunology·G DelespesseA Dalloul
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 21, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D WidneyO Martínez-Maza
Aug 23, 2002·Current Opinion in Oncology·Otoniel Martínez-Maza, Elizabeth Crabb Breen
Apr 2, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·David J AmrolJohn J Murray
Jan 25, 2006·Clinical and Laboratory Haematology·B SakaG Dinçol
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 14, 2010·Clinical and Experimental Immunology·M AcharyaW Cushley
Apr 30, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth Crabb BreenOtoniel Martinez-Maza
Sep 17, 2011·Immunology Letters·Barbara PlatzerEdda Fiebiger
Aug 1, 2012·Cancer Research·Anneclaire J De RoosOtoniel Martínez-Maza
Dec 20, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shehnaz K HussainOtoniel Martínez-Maza
Jun 1, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yu GuoOtoniel Martínez-Maza
Sep 21, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shehnaz K HussainOtoniel Martínez-Maza
May 17, 2014·International Journal of Cancer. Journal International Du Cancer·Lauren R TerasSusan M Gapstur
Dec 30, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rudolf KaaksAlexandra Nieters
Jun 23, 2015·International Journal of Cancer. Journal International Du Cancer·Bryan A BassigNathaniel Rothman
Oct 2, 2015·Current Topics in Microbiology and Immunology·Jane A Healy, Sandeep S Dave
Dec 20, 2015·International Journal of Cancer. Journal International Du Cancer·Fatemeh Saberi HosnijehRoel Vermeulen
Oct 18, 2016·Current Opinion in HIV and AIDS·Meredith S Shiels, Eric A Engels

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