Elevated soluble intercellular adhesion molecule-1 levels are associated with poor short-term prognosis in middle-aged patients with acute ischaemic stroke

International Journal of Cardiology
Loukianos S RallidisDimitrios Th Kremastinos

Abstract

There is increasing evidence that cellular adhesion molecules (CAMs) play an important role in the pathophysiology of acute ischaemic stroke. We examined the prognostic value of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) on in-hospital mortality in patients with ischaemic stroke. We recruited 241 consecutive patients <or=65 years of age who were admitted with acute ischaemic stroke. Serum levels of sICAM-1 and sVCAM-1 were determined within 12 h from admission. Seventy-six subjects without evidence of cardiovascular disease, matched for age and sex, served as controls. Patients with acute ischaemic stroke had higher sICAM levels compared to controls [267 (220-325) versus 200 (179-225) ng/ml, p<0.001]. Sixteen (6.6%) patients died during hospitalization. sICAM-1 and sVCAM-1 levels were significantly higher in patients who died compared to those who survived [370 (324-453) versus 260 (219-313) ng/ml, p<0.001 and 790 (495-985) versus 576 (494-671) ng/ml, p=0.01, respectively] but only sICAM-1 levels were independently associated with early death, after adjusting for various confounding factors. For 10 ng/ml increase in sICAM-1 levels there was a 9% higher risk of dyi...Continue Reading

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Citations

May 16, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Craig J SmithAdam Denes
Nov 19, 2009·Journal of Translational Medicine·Shaheen E LakhanMagdalena Hofer
Aug 30, 2011·Journal of Translational Medicine·Tanya BogoslovskySteven Warach
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Aug 11, 2018·Therapeutic Advances in Neurological Disorders·Laura RamiroJoan Montaner
Apr 4, 2021·International Journal of Molecular Sciences·Mercedes UnzetaMontse Solé
Mar 31, 2021·Neurochemistry International·Satoshi HosokiMasafumi Ihara
Jun 14, 2021·Clinical and Experimental Medicine·Ana Lucia Cruz Fürstenberger LehmannEdna Maria Vissoci Reiche

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