Elevated systemic inflammatory responses, factors associated with physical and mental quality of life, and prognosis of hepatocellular carcinoma.

Aging
Yang DengJian Gu

Abstract

Impaired quality of life (QOL) is common in hepatocellular carcinoma (HCC) patients. In this study, we used a large hospital-based multiethnic HCC patient cohort to systematically identify factors associated with QOL and investigate the prognostic value of QOL.The Short Form-12 questionnaire was used to assess QOL. The Physical Component Summary (PCS) and Mental Component Summary (MCS) scores were categorized into three groups (low, medium, and high) and ordered logistic regression analysis was used to analyze the association of PCS and MCS scores with patient characteristics. The association of PCS and MCS scores with mortality was assessed by Cox regression analysis.Notably, a panel of elevated systemic inflammatory response markers was associated with poor QOL. Other significant factors associated with QOL included age, liver function, sex, smoking, HCC etiology, and major clinical features. Patients with low (hazard ratio [95% CI], 1.72 [1.36-2.17]) and medium (1.52 [1.23-1.89]) PCS scores exhibited higher risks of death compared to patients with high PCS score. The association of MCS with the risk of death was not significant. These observations were consistent across all the different ethnicities.The identified factors as...Continue Reading

References

Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E R GritzE Abemayor
Feb 16, 2006·Family Practice·Emmanuel ScheppersJoost Dekker
Apr 8, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W YeoB Zee
Nov 18, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Yan-Bin WangShan-Shan Yin
Nov 23, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jennifer L SteelBrian I Carr
Feb 14, 2007·Journal of Gastroenterology and Hepatology·Yuji KondoMasao Omata
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Dec 15, 2007·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Jennifer R PiazzaDavid M Almeida
Jan 17, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shiow-Ching ShunYa-Li Hsiao
Jul 12, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Franck BonnetainLaurent Bedenne
Mar 23, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sheng-Yu FanMing-Chih Ho
Apr 19, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Bram BalduyckPaul Van Schil
Aug 13, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yoon Hee ChunSang Hoon Ahn
Mar 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN European Association for Study of Liver, UNKNOWN European Organisation for Research and Treatment of Cancer
Apr 13, 2012·Cancer Nursing·Alicia K MatthewsClara Manfredi
Aug 2, 2014·Journal of Gastrointestinal Oncology·Shipra GandhiRenuka Iyer
Oct 5, 2014·The Lancet Oncology·Connie I DiakosStephen J Clarke
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 14, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sarah J DansonChristine Eiser
Oct 4, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Campbell S D Roxburgh, Donald C McMillan
Nov 26, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chantal QuintenUNKNOWN EORTC Clinical Groups
Dec 22, 2015·International Journal of Epidemiology·Xifeng WuStanley R Hamilton
Jun 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barry J A LairdDonald C McMillan
Aug 15, 2017·World Journal of Hepatology·Leung Li, Winnie Yeo
Sep 25, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Malin Sternby EilardMagnus Rizell
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
Feb 2, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Andrea GmürJean-François Dufour
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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surgical resection

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