Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in Strongyloides Stercoralis Infection that Diminish following Treatment

Frontiers in Immunology
Anuradha RajamanickamSubash Babu

Abstract

Infection with the helminth parasite Strongyloides stercoralis (Ss) is commonly clinically asymptomatic that is often accompanied by peripheral eosinophilia. Granulocytes are activated during helminth infection and can act as immune effector cells. Plasma levels of eosinophil and neutrophil granular proteins convey an indirect measure of granulocyte degranulation and are prominently augmented in numerous helminth-infected patients. In this study, we sought to examine the levels of eosinophil, neutrophil, and mast cell activation-associated granule proteins in asymptomatic Ss infection and to understand their kinetics following anthelmintic therapy. To this end, we measured the plasma levels of eosinophil cationic protein, eosinophil-derived neurotoxin, eosinophil peroxidase, eosinophil major basic protein, neutrophil elastase, myeloperoxidase, neutrophil proteinase-3, mast cell tryptase, leukotriene C4, and mast cell carboxypeptidase-A3 in individuals with asymptomatic Ss infection or without Ss infection [uninfected (UN)]. We also estimated the levels of all of these analytes in infected individuals following definitive treatment of Ss infection. We demonstrated that those infected individuals have significantly enhanced plasm...Continue Reading

References

Apr 18, 1991·The New England Journal of Medicine·P F Weller
Sep 1, 1995·The American Journal of Tropical Medicine and Hygiene·Y SatoY Shiroma
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K L DenzlerJ J Lee
Jan 4, 2001·Current Opinion in Hematology·G M Walsh
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K L DenzlerN A Lee
Mar 5, 2002·Parasite Immunology·De'broski R HerbertDavid Abraham
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Amy D Klion, Thomas B Nutman
Jan 27, 2004·The Journal of Parasitology·Ariela Freudenstein-DanZvi Fishelson
Oct 2, 2004·Nature Reviews. Immunology·Jean S Marshall
Oct 7, 2004·International Archives of Allergy and Immunology·Harissios VliagoftisRedwan Moqbel
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·André GessnerMarkus Mohrs
Jun 16, 2005·Current Opinion in Immunology·Joost J Oppenheim, De Yang
Oct 8, 2005·Chemical Immunology and Allergy·Joanne L Pennock, Richard K Grencis
Aug 2, 2006·Parasite Immunology·A MirS Rull
Aug 26, 2006·Immunology and Allergy Clinics of North America·Lawrence B Schwartz
Sep 18, 2007·Immunology and Allergy Clinics of North America·Li Zuo, Marc E Rothenberg
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Kelly D StoneDean D Metcalfe
Feb 16, 2011·Clinical Science·Charlotte L WellerJonathan R Lamb
Jul 26, 2011·Nature Reviews. Immunology·Alberto MantovaniSébastien Jaillon
Nov 22, 2011·Immunologic Research·Sandra Bonne-AnnéeDavid Abraham
Jun 27, 2013·Infection and Immunity·Sandra Bonne-AnnéeDavid Abraham
Jan 16, 2014·PLoS Neglected Tropical Diseases·Zeno BisoffiThomas B Nutman
Aug 15, 2014·PLoS Neglected Tropical Diseases·Santhosh PuthiyakunnonXiaoguang Chen
Sep 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jesica A HerrickThomas B Nutman
Nov 28, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lu HuangJudith A Appleton
Feb 11, 2015·PLoS Neglected Tropical Diseases·Dora BuonfrateZeno Bisoffi
Aug 25, 2015·Frontiers in Immunology·Silvia Bulfone-Paus, Rajia Bahri
Jun 6, 2016·Trends in Parasitology·Lu Huang, Judith A Appleton

❮ Previous
Next ❯

Citations

Nov 20, 2018·The Journal of Infectious Diseases·Karin de RuiterMaria Yazdanbakhsh
Mar 11, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eva ClarkRojelio Mejia
Jun 6, 2018·Frontiers in Immunology·Lu LuEster Boix
Sep 5, 2018·Trends in Parasitology·Juan M Inclan-Rico, Mark C Siracusa
Nov 24, 2019·The Medical Clinics of North America·Fei Li Kuang
Mar 22, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Kathleen T LuskinJonathan J Lyons
Jul 28, 2020·La Revue de médecine interne·H LobbesS Durupt

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
blood draws

Software Mentioned

GraphPad PRISM
JMP
GraphPad

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.