Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea: a case report

Pediatric Transplantation
M FrühwirthH Ellemunter

Abstract

The combination of tacrolimus (TAC) and mycophenolate mofetil (MMF) is frequently used for immunosuppression after organ transplantation (Tx), but the pharmacokinetics and interactions between the two drugs are poorly elucidated. We describe here the increase of TAC trough levels during MMF-induced diarrhea in a 8-yr-old boy after kidney Tx. Early dose reduction of TAC, together with short-term monitoring of TAC trough levels in the presence of diarrhea, is recommended.

References

Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·G FillerJ H Ehrich
Dec 5, 1998·Transplantation Proceedings·Y WatanabeK Kawachi
Dec 29, 1998·Transplantation Proceedings·F BraunB Ringe
Mar 10, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J F RenzJ P Roberts
Jun 8, 1999·Pediatric Transplantation·A M Neu, M Benfield

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Citations

Nov 28, 2002·Pediatric Transplantation·Raymond Reding
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wim LemahieuYves Vanrenterghem
Sep 16, 2004·Pediatric Transplantation·Jameela A Kari, Richard S Trompeter
Dec 21, 2004·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·I J DalleK Geboes
Oct 24, 2002·Current Opinion in Nephrology and Hypertension·David W Holt
Sep 8, 2012·Transplantation·Gerben A J van BoekelLuuk B Hilbrands
Jul 13, 2004·Clinical Pharmacokinetics·Christine E Staatz, Susan E Tett
Dec 9, 2008·Current Opinion in Organ Transplantation·David J Riddle, Erik R Dubberke

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