Elevated tau and interleukin-6 concentrations in adults with obstructive sleep apnea

Sleep Medicine
Vida MotamediJessica Gill

Abstract

Obstructive sleep apnea (OSA) is characterized by apneas and hypopneas that result in hypoxia, cerebral hypoperfusion, endothelial dysfunction, inflammation, and oxidative stress. These pathophysiologic processes likely contribute to neuronal damage. Tau is a protein that stabilizes microtubules and, along with amyloid beta (Aβ), is associated with neurodegenerative processes. We sought to determine if tau and other biomarkers of inflammation were related to OSA severity. Concentrations of tau, Aβ40, Aβ42, c-reactive protein (CRP), TNF-α, interleukin (IL)-6, and IL-10 were measured in blood and compared between participants with moderate-severe OSA (n = 28), those with mild OSA (n = 22), and healthy controls (n = 24). The cohort included relatively young, primarily male active duty military personnel without a history of traumatic brain injury or neurodegenerative disease. Total biomarker concentrations were determined from plasma samples using an ultra-sensitive detection method, Simoa™, and CRP was assayed by ELISA. Total tau and IL-6 concentrations were elevated in participants with moderate-severe OSA, with a mean apnea-hypopnea index (AHI) of 26.1/h, compared to those with mild OSA (mean AHI 8.6/h) and healthy controls (me...Continue Reading

References

May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A N VgontzasG P Chrousos
Jun 17, 2000·The American Journal of Medicine·J M McCord
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Kaj Blennow
Feb 10, 2006·Southern Medical Journal·E KasasbehG Krishnaswamy
May 9, 2006·Free Radical Biology & Medicine·Yuichiro J SuzukiRegina M Day
Nov 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiulian SunWeihong Song
Sep 18, 2008·Journal of the American Geriatrics Society·Sonia Ancoli-IsraelJose S Loredo
Jan 23, 2009·The Journal of Head Trauma Rehabilitation·Heidi TerrioDeborah Warden
Mar 3, 2009·Journal of Sleep Research·Khalid YaouhiBéatrice Desgranges
Sep 30, 2009·Respiration; International Review of Thoracic Diseases·Lena Lavie, Vsevolod Polotsky
Sep 18, 2010·Journal of Alzheimer's Disease : JAD·Mordhwaj S Parihar, Gregory J Brewer
Oct 5, 2010·NeuroImage·Federico TorelliCharles R G Guttmann
Nov 30, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Luciano F DragerVsevolod Y Polotsky
Jan 10, 2013·Journal of Rehabilitation Research and Development·Paul R KingScott T Meier
Aug 21, 2013·Journal of Alzheimer's Disease : JAD·Satomi ShiotaKazuhisa Takahashi
Dec 30, 2014·Pulmonary Medicine·Konstantinos ArchontogeorgisPaschalis Steiropoulos
Sep 14, 2017·Brain : a Journal of Neurology·Yo-El S JuDavid M Holtzman

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Citations

Feb 26, 2019·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·Kara ManchesterJingzhen Yang
May 6, 2020·Sleep·Aditya AmbatiShahrad Taheri
Nov 28, 2020·Scientific Reports·Thom S LysenAnnemarie I Luik
Dec 8, 2020·CNS Spectrums·Nguy Thi Bich HanhJiunn-Horng Kang
Oct 7, 2020·Sleep Medicine Reviews·Claudio LiguoriBiancamaria Guarnieri
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Luigi Ferini-StrambiMaria Salsone
Jul 1, 2019·International Journal of Head and Neck Surgery·Pamela BarlettaAlejandro D Chediak

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