Elevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosacea

Ocular Immunology and Inflammation
Nesrin Büyüktortop GökçınarFatma Azize Budak Yıldıran

Abstract

To investigate the role of innate immunity in ocular rosacea. Thirty-two patients with ocular rosacea patients (group-1) and 28 healthy volunteers (group-2) who served as controls were enrolled in the study. Tear function parameters were assessed, conjunctival impression cytology was performed and tear samples were collected. Human-neutrophil-peptides (HNP) 1-3 and human-beta-defensin-2 (hBD-2) levels were measured in tears by using ELISA tests. Cathelicidin leucin-leucin-37 (LL-37), hBD-2, human-beta-defensin-9 (hBD-9) gene expression levels were measured in the conjunctival impression cytology samples using real-time polymerase chain reaction. Tear HNP1-3 (p = 0.024), hBD-2 (p < 0.001), conjunctival LL-37 gene expression rate (p = 0.014) and ocular surface disease index scores (p = 0.001) were higher and the tear break-up time was lower (p = 0.003) in group-1. No other differences were found between the groups. The results of this study suggest the role of abnormal innate immunity in the pathophysiology of ocular rosacea by revealing elevated antimicrobial peptide levels.

References

May 26, 1999·The British Journal of Ophthalmology·R J HaynesH S Dua
Aug 27, 2003·Investigative Ophthalmology & Visual Science·Srihari NarayananAlison M McDermott
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·G Sandra TjabringaPieter S Hiemstra
May 22, 2004·Journal of the American Academy of Dermatology·Jonathan WilkinUNKNOWN National Rosacea Society Expert Committee
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Richard S McIntoshHarminder S Dua
Nov 22, 2005·The British Journal of Ophthalmology·R SinghH S Dua
Jan 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marko MäättäTimo Sorsa
May 26, 2006·Investigative Ophthalmology & Visual Science·Ling C HuangAlison M McDermott
Aug 7, 2007·Nature Medicine·Kenshi YamasakiRichard L Gallo
Jan 4, 2008·Investigative Ophthalmology & Visual Science·Asiya AbedinHarminder S Dua
Apr 16, 2009·Clinical Microbiology Reviews·Trine H Mogensen
Sep 2, 2009·The Journal of Allergy and Clinical Immunology·Jürgen Schauber, Richard L Gallo
Feb 2, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eduardo Guaní-GuerraLuis M Terán
May 18, 2011·Cellular and Molecular Life Sciences : CMLS·Satya S Kolar, Alison M McDermott
Nov 15, 2011·The Journal of Investigative Dermatology. Symposium Proceedings·Kenshi Yamasaki, Richard L Gallo
Nov 15, 2011·The Journal of Investigative Dermatology. Symposium Proceedings·Ulf Meyer-Hoffert, Jens-Michael Schröder
Nov 15, 2011·The Journal of Investigative Dermatology. Symposium Proceedings·Verena D SchwabMartin Steinhoff
Jan 11, 2012·Investigative Ophthalmology & Visual Science·Ahmad Muneer OtriHarminder S Dua
Jan 30, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Andreas PosaFriedrich Paulsen
Jan 31, 2013·International Reviews of Immunology·James T Rosenbaum, Hyun Woong Kim
Jan 31, 2013·International Reviews of Immunology·Robert B NussenblattH Nida Sen
Feb 2, 2013·Investigative Ophthalmology & Visual Science·Rachel L RedfernAlison M McDermott
Apr 16, 2013·The Ocular Surface·Srihari NarayananAlison M McDermott
May 8, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Markus ReinholzJürgen Schauber
Jun 5, 2013·Ocular Immunology and Inflammation·Pinar Topcu-YilmazIlhan Tezcan
Oct 26, 2013·Nature Reviews. Immunology·Albert C ShawRuth R Montgomery
Nov 28, 2013·Journal of the American Academy of Dermatology·Martin SteinhoffJames J Leyden
Nov 28, 2013·Journal of the American Academy of Dermatology·Ana Carolina Vieira, Mark J Mannis
Nov 2, 2016·Turkish Journal of Ophthalmology·İlkay Kılıç Müftüoğlu, Yonca Aydın Akova
Jun 8, 2017·Progress in Retinal and Eye Research·Imran MohammedHarminder S Dua
Jun 18, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·L I GonserM Schaller
Jul 25, 2017·The Ocular Surface·James S WolffsohnJennifer P Craig
Nov 2, 2017·Journal of the American Academy of Dermatology·Richard L GalloDiane Thiboutot
Mar 14, 2018·Ocular Immunology and Inflammation·Dilay OzekFerda Artüz

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Citations

Jun 27, 2020·European Journal of Ophthalmology·Sayena JabbehdariAli R Djalilian
Jan 17, 2021·International Journal of Molecular Sciences·Youssof EshacVinay Kumar Aakalu
Nov 3, 2021·International Ophthalmology·Taylan OzturkCanan Asli Utine

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