Elevated threshold for intracortical inhibition in focal hand dystonia

Movement Disorders : Official Journal of the Movement Disorder Society
Cathy M Stinear, Winston D Byblow

Abstract

Differences between control and focal hand dystonia (FHD) subject groups in short interval intracortical inhibition (SICI) as determined by paired transcranial magnetic stimulation (TMS) can be difficult to demonstrate, due to interindividual differences. The purpose of this study was to compare two TMS methods for assessing SICI in 8 control and 7 FHD subjects. Electromyographic (EMG) data were recorded from the first dorsal interosseous (FDI) muscle of the dominant hands of the control subjects and affected hands of the FHD subjects. The first method used a conventional approach of setting conditioning stimulus intensity to 80% of rest threshold (RTh) and test stimulus intensity to 120% RTh. Three interstimulus intervals (ISIs) were used: 2 msec, 3 msec, and the ISI between 2 and 3 msec that produced optimal SICI. The second method was novel in that test stimulus intensity was set to 150% active threshold (ATh), and conditioning stimulus intensity was varied between 50% and 100% ATh. The latter was determined at the threshold for SICI and expressed as a ratio of ATh. There was no difference between the subject groups in the degree of SICI produced using the first method, at the three ISIs studied. However, using the second me...Continue Reading

References

Apr 1, 1990·Trends in Neurosciences·C D Marsden, M P Sheehy
Sep 1, 1982·Brain : a Journal of Neurology·M P Sheehy, C D Marsden
Nov 1, 1993·The Journal of Physiology·T KujiraiC D Marsden
Sep 1, 1995·The Journal of Physiology·M C RiddingJ C Rothwell
Nov 1, 1996·The Journal of Physiology·U ZiemannM C Ridding
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·S RonaM Manfredi
May 12, 1998·The Journal of Physiology·R HanajimaI Kanazawa
Sep 28, 1998·Annals of Neurology·D EidelbergS Fahn
Mar 7, 2002·Experimental Brain Research·R J FisherH Bostock
Mar 19, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fumiko MaedaAlvaro Pascual-Leone
Jun 29, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Eric M Wassermann
Jun 13, 2003·Experimental Brain Research·Lailoma RoshanRobert Chen
Jun 28, 2003·Experimental Brain Research·Ritsuko HanajimaYoshikazu Ugawa

❮ Previous
Next ❯

Citations

Mar 9, 2010·Brain : a Journal of Neurology·Karin Rosenkranz
Dec 17, 2008·Cerebral Cortex·Siobhan M SchabrunMichael C Ridding
Feb 7, 2007·Journal of Cognitive Neuroscience·Julie DuqueLeonardo G Cohen
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karin RosenkranzJohn C Rothwell
Jun 19, 2013·Brain : a Journal of Neurology·Maja KojovicMark J Edwards
Nov 9, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tommaso BocciFerdinando Sartucci
Mar 23, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Penelope TalelliJohn C Rothwell
Feb 9, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Richard L Harvey, James W Stinear
Dec 18, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·R AránguizM León
Sep 8, 2010·Neurobiology of Disease·Mark Hallett
May 14, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Heike RussmannMark Hallett
Feb 17, 2009·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Leighton B N HinkleySrikantan S Nagarajan
Sep 16, 2008·Neuroscience and Biobehavioral Reviews·Cathy M StinearWinston D Byblow
Dec 8, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert ChenUlf Ziemann
Jun 16, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Suzanne J AckerleyWinston D Byblow
Feb 12, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·UNKNOWN Sabine MeunierUNKNOWN Marie Vidailhet
Jan 5, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Giacomo KochJohn C Rothwell
Mar 21, 2012·The European Journal of Neuroscience·Sabine MeunierMark Hallett
Apr 16, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·David H BenningerMark Hallett
May 13, 2014·The European Journal of Neuroscience·Panagiotis KassavetisMark J Edwards
Apr 23, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Stefano AmadioUbaldo Del Carro
May 9, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Carlo TrompettoGiovanni Abbruzzese
Jun 4, 2013·Neuroscience and Biobehavioral Reviews·April L PhilpottNellie Georgiou-Karistianis
Jan 21, 2015·Parkinsonism & Related Disorders·Elisa R FerrèPatrick Haggard
Jan 29, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Anna SadnickaMark Edwards
Jun 20, 2015·Neurorehabilitation and Neural Repair·Sharyl SamargiaTeresa Jacobson Kimberley
Jan 29, 2011·Stroke; a Journal of Cerebral Circulation·Jodi D EdwardsLara A Boyd
Nov 11, 2006·Medicine and Science in Sports and Exercise·Cathy M StinearWinston D Byblow
Jun 15, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Cathy M Stinear, Winston D Byblow
Feb 24, 2006·Journal of Neurophysiology·James P CoxonWinston D Byblow
Apr 14, 2019·Brain Sciences·Phillip DesrochersFlorian Kagerer
Oct 9, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Antonella ConteAlfredo Berardelli
Mar 22, 2008·Brain : a Journal of Neurology·Cathy M StinearWinston D Byblow
Nov 29, 2016·Frontiers in Neural Circuits·Pierre LozeronNathalie Kubis
Sep 30, 2020·The European Journal of Neuroscience·Alana B McCambridge, Lynley V Bradnam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.