Elevated Troponin Serum Levels in Adult Onset Still's Disease

Case Reports in Rheumatology
Carlo Umberto ManziniClodoveo Ferri

Abstract

Adult onset Still's disease (AOSD) is a rare inflammatory systemic disease that occasionally may affect myocardium. Diagnosis is based on typical AOSD symptoms after the exclusion of well-known infectious, neoplastic, or autoimmune/autoinflammatory disorders. In the case of abrupt, recent onset AOSD, it could be particularly difficult to make the differential diagnosis and in particular to early detect the possible heart involvement. This latter event is suggested by the clinical history of the four patients described here, incidentally observed at our emergency room. All cases were referred because of acute illness (high fever, malaise, polyarthralgias, skin rash, and sore throat), successively classified as AOSD, and they presented abnormally high levels of serum troponin without overt symptoms of cardiac involvement. The timely treatment with steroids (3 cases) or ibuprofen (1 case) leads to the remission of clinicoserological manifestations within few weeks. These observations suggest that early myocardial injury might be underestimated or entirely overlooked in patients with AOSD; routine cardiac assessment including troponin evaluation should be mandatory in all patients with suspected AOSD.

References

Jun 1, 1992·Internal Medicine·S HosakaS Kashiwazaki
Jun 1, 1990·International Journal of Cardiology·R N SachsJ Lanfranchi
Feb 1, 1987·Arthritis and Rheumatism·J J CushL A Cooperstein
Sep 1, 1994·Clinical Rheumatology·A FalkenbachW Caspary
Oct 1, 1995·European Heart Journal·D Zenagui, J P De Coninck
Nov 11, 2005·Acta Clinica Belgica·F VandergheynstG Decaux
May 9, 2006·La Revue de médecine interne·I Ben GhorbelJacques Pouchot
Aug 2, 2007·Rheumatology International·W H Yoo
Jul 7, 2009·Rheumatology International·Javier Alberto CavallascaGuillermo A Tate
Dec 19, 2009·Rheumatology International·Valentina BagnariFrancesco Trotta
Aug 31, 2011·Rheumatology International·Qinjin HuJian Zhong
Nov 18, 2011·Reumatología clinica·Gema García-GarcíaSara Sánchez Giralt
May 3, 2012·Current Problems in Cardiology·Allan S Jaffe
Jan 28, 2014·International Journal of Cardiology·Andrew D ChoiGaby Weissman
Mar 25, 2014·Autoimmunity Reviews·Mathieu Gerfaud-ValentinPascal Sève
Mar 26, 2014·The American Journal of Emergency Medicine·Adriana AcostaMirta Diez
Jun 6, 2014·BMJ Case Reports·Filipe André GonzalezMargarida Lopes Coelho
Nov 13, 2014·Immunologic Research·Yvan JamillouxPascal Sève

❮ Previous
Next ❯

Citations

Nov 21, 2019·Clinical Rheumatology·Abraham Edgar Gracia-Ramos, Joshua Antonio Contreras-Ortíz
Jun 2, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Fabio MarazziVincenzo Valentini

❮ Previous
Next ❯

Methods Mentioned

BETA
ESR
X-ray
biopsy

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
J LieseC Moench
Deutsche medizinische Wochenschrift
C Dechant, K Krüger
Journal of the Royal Society of Medicine
A B Bhanji, F E Bruckner
© 2021 Meta ULC. All rights reserved