Elevated white blood cell synthesis of leukotriene C4 in chronic myelogenous leukaemia but not in polycythaemia vera

British Journal of Haematology
L StenkeJ A Lindgren

Abstract

Leukotriene (LT) formation was studied in ionophore A23187-stimulated white blood cell (WBC) preparations from patients with chronic myelogenous leukaemia (CML; n = 14), polycythaemia vera (PV; n = 10) and two control groups consisting of patients with non-malignant inflammatory disease (n = 4) and normal healthy donors (n = 25). The synthesized products were identified and quantitated using high-performance liquid chromatography combined with computerized UV-spectroscopy. White blood cell preparations from the CML patients produced more LTC4 (40.2 +/- 7.9 pmol/10(6) WBC, mean +/- SEM) than WBC from the healthy donors (9.0 +/- 1.8), P less than 0.0005. In contrast, the formation of LTB4 was normal and there was no increase in the total leukotriene synthesis (the sum of LTC4, LTB4, 20-OH-LTB4 and the delta 6-trans-isomers of LTB4). The ratio between leukotrienes C4 and B4 was strongly elevated in the CML group; 1.67 +/- 0.25 v. 0.37 +/- 0.07 in the controls, P less than 0.0005. No significant correlation was observed between the levels of LTC4 and the number of known LTC4 producing cells (such as monocytes, eosinophils and basophils) in the CML WBC preparations. In contrast, a correlation was found between the sum of neutrophili...Continue Reading

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Citations

Jul 1, 1996·Critical Reviews in Oncology/hematology·C Denzlinger
Oct 18, 2006·The Journal of Experimental Medicine·Melissa Kristine MiddletonEllen Puré
Mar 11, 2004·British Journal of Haematology·Cecilia RoosSusanne Tornhamre
Sep 16, 2011·Lipids in Health and Disease·Undurti N Das, N Madhavi
Dec 10, 2016·Leukemia & Lymphoma·Elham Yektaei-KarinLeif Stenke
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Jan 1, 1993·Medical Oncology and Tumor Pharmacotherapy·P Reizenstein, L Stenke

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