Elevation of {beta}-amyloid 1-42 autoantibodies in the blood of amnestic patients with mild cognitive impairment

Archives of Neurology
Daniela StoraceMassimo Tabaton

Abstract

To develop a blood-based test for screening populations at risk for Alzheimer disease. Case-control study. Subjects A total of 180 patients with mild cognitive impairment (MCI) and 105 age-matched, cognitively normal controls. The titer of beta-amyloid 1-42 autoantibodies in the plasma was obtained at the time of diagnosis and evaluated by enzyme-linked immunosorbent assay before and after dissociation of the antigen-antibody complexes. A total of 107 patients with MCI were followed up for 36 months; 70 of the 107 cases progressed to Alzheimer disease. The average level of beta-amyloid 1-42 plasma autoantibodies in patients with MCI that progressed to Alzheimer disease, but not that of the stable cases, was significantly higher than in cognitively normal controls (P < .001). The results suggest that the plasma beta-amyloid 1-42 autoantibodies parallel beta-amyloid 42 deposition in the brain, which is known to precede by several years the clinical onset of Alzheimer disease. The evaluation of beta-amyloid 1-42 autoantibodies after dissociation of the complexes is a simple and inexpensive method that can be used to predict the occurrence of Alzheimer disease.

Citations

Mar 14, 2013·PloS One·Nicola MarchiDamir Janigro
Oct 23, 2012·Alzheimer's Research & Therapy·Hugo VandersticheleAndreas Jeromin
Nov 5, 2014·Brain Structure & Function·Gabriel Gonzalez-EscamillaJose L Cantero
Nov 26, 2011·The International Journal of Neuroscience·Sanxi AiBeisha Tang
May 31, 2014·BioMed Research International·Beatrice ArosioDaniela Mari
Apr 1, 2014·Brain Structure & Function·Gabriel Gonzalez-EscamillaJose L Cantero
Dec 15, 2010·Biogerontology·Patrizio Odetti, Ettore Bergamini
Dec 8, 2015·Journal of Alzheimer's Disease : JAD·Martin KleinschmidtHans-Ulrich Demuth
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Sofia SöllvanderDag Sehlin
Jul 25, 2019·Frontiers in Immunology·Yannick ChantranPierre Aucouturier
Aug 28, 2019·International Journal of Molecular Sciences·Vo Van GiauSeong Soo A An

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