Elevation of brain 5-HT activity, POMC expression, and plasma cortisol in socially subordinate rainbow trout

The American Journal of Physiology
S Winberg, O Lepage

Abstract

Agonistic behavior, brain concentrations of serotonin (5-hydroxytryptamine, 5-HT), and 5-hydroxyindoleacetic acid (5-HIAA, the main 5-HT metabolite), plasma cortisol levels, and the pituitary expression of pro-opiomelanocortin (POMC) A and B mRNA were determined in socially dominant and subordinate rainbow trout after 1 or 7 days of social interaction. Telencephalic and brain stem 5-HIAA/5-HT ratios, plasma cortisol levels, and pituitary POMC mRNA concentrations were elevated in fish being subordinate for 1 day. Furthermore, neither telencephalic 5-HIAA/5-HT ratios nor pituitary POMC A or POMC B mRNA expression showed any decline after 7 days of social interaction. By contrast, plasma cortisol concentrations of subordinate fish declined after 7 days but were still significantly higher than in dominant fish. Furthermore, in subordinate fish, hypothalamic 5-HIAA/5-HT ratios and plasma cortisol levels were highly correlated, suggesting an important role of hypothalamic 5-HT in the regulation of the teleost hypothalamic-pituitary-interrenal (HPI) axis. The number of aggressive acts received and plasma cortisol levels were highly correlated in 1-day subordinates, a relationship not seen in fish subjected to 1 wk of subordination. Th...Continue Reading

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Citations

Oct 5, 2007·Brain, Behavior and Evolution·Joachim Schjolden, Svante Winberg
Nov 25, 2011·Fish Physiology and Biochemistry·Tim EllisCatarina I M Martins
Nov 23, 2017·Frontiers in Neuroscience·Yuki HiguchiIshwar S Parhar
Feb 8, 2006·Biological Reviews of the Cambridge Philosophical Society·Yuying HsuLarry L Wolf
Jan 4, 2012·Fish Physiology and Biochemistry·Luis E C ConceiçãoLluis Tort
Jul 6, 2011·Fish Physiology and Biochemistry·Joël AttiaBørge Damsgård
Dec 8, 2019·Fish Physiology and Biochemistry·Han Seok RyuCheol Young Choi
Apr 15, 2020·PloS One·Leia RogersRafael Freire
Jun 6, 2020·Frontiers in Behavioral Neuroscience·Xiaoqiang SunShuqiao Yao
Aug 5, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K M GilmourJ G Richards
Jul 30, 2019·Frontiers in Endocrinology·Marcelino HerreraBenjamín Costas
Nov 22, 2020·General and Comparative Endocrinology·Paula G VissioTomás H Delgadin
Jan 5, 2011·Physiology & Behavior·Christina SørensenGöran E Nilsson
Mar 8, 2003·The Journal of Experimental Biology·Philip K StoddardVielka L Salazar
Nov 23, 2006·The Journal of Experimental Biology·Cliff H Summers, Svante Winberg
Sep 11, 2003·The Journal of Experimental Biology·Olivier LepageSvante Winberg
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Marcos Antonio López-PatiñoJuan Antonio Martos-Sitcha
Feb 27, 2007·Physiology & Behavior·Alison M BellSvante Winberg
Nov 26, 2008·General and Comparative Endocrinology·Joachim SchjoldenEarl T Larson
Sep 10, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Benjamín CostasLuís E C Conceição

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