Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis

Acta neurologica Belgica
Lukas MachGuy S Reeder

Abstract

Limited evidence suggests that specificity of cardiac troponin T (cTnT), a highly sensitive biomarker of myocardial injury, is reduced in patients with skeletal myopathies. Whether amyotrophic lateral sclerosis (ALS)-the most common motor neuron disease-could be also associated with abnormal plasma or serum cTnT levels remains unclear. Our objective was to assess cTnT levels in patients with ALS without known cTnT elevating conditions. Among ALS patients seen at our institution until 2012 we identified those who had their cTnT measured. Patients who suffered from conditions known to elevate cTnT were excluded. A case-control analysis comparing cTnT levels of these ALS patients to matched non-ALS controls fulfilling the same inclusion criteria was performed. We included 40 ALS patients of whom 27 (68 %) patients had a positive cTnT. In the control group (n = 40), 2 (5 %) tested as cTnT positive (p < 0.001). Among the ALS patients who underwent cTnT evaluation on more occasions (n = 7; median follow-up = 1.08 years), 2 (29 %) patients tested positive during the initial measurement while 6 (86 %) of them had positive cTnT at the subsequent evaluations. ALS patients with increased cTnT had been diagnosed with ALS significantly earl...Continue Reading

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Citations

Nov 21, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Nov 3, 2017·Acta neurologica Belgica·Mario Casmiro, Alessandro Graziani
Apr 19, 2017·Journal of Cachexia, Sarcopenia and Muscle·Zherong XuTan Zhang
Jun 22, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Ulf KläppeCaroline Ingre

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