Elevation of cardiac troponins in exacerbation of chronic obstructive pulmonary disease

Emergency Medicine Australasia : EMA
Martyn G Harvey, Robert J Hancox

Abstract

To investigate the prevalence of serum troponin elevation in patients admitted to hospital with an exacerbation of chronic obstructive pulmonary disease (COPD). We examined the records of all patients admitted to hospital for treatment of COPD for serum troponin measurement, clinical features of myocardial ischaemia, oxygenation (pulse oximetry, arterial blood gas analysis), spirometry, and duration of admission. Troponin elevation was observed in 58 of 235 (25%) presentations in which troponin was measured. Despite the troponin result, only seven of these 58 patients had been diagnosed with an acute coronary syndrome. New ECG evidence of ischaemia was uncommon. Patients with raised troponins tended to be older (75.7 vs 70.0 years, P = 0.001), had lower pulse oximetry (85.6% vs 89.6%, P = 0.003), were more acidotic (pH 7.34 vs 7.40, P= 0.002) and more hypercapnoeic (pCO2 58.0 vs 49.1, P = 0.04). There were no significant differences in serum creatine kinase. Patients with raised troponins had significantly longer admissions (5 vs 3 days, P = 0.001). Serum troponins are commonly raised in acute exacerbations of COPD and appear to reflect the severity of the exacerbation. In the majority of patients there is insufficient evidence...Continue Reading

References

Nov 14, 1997·Journal of the American College of Cardiology·B LauerH P Schultheiss
Apr 29, 1998·Chest·C SpiesW Schaffartzik
Nov 18, 2000·Journal of the American College of Cardiology·T MeyerA B Buchwald
May 30, 2001·The American Journal of Cardiology·R R BrandtP Hanrath
Apr 4, 2002·Postgraduate Medical Journal·I WeinbergT Chajek-Shaul
Nov 5, 2002·Internal Medicine Journal·T K BakshiG P Armstrong

❮ Previous
Next ❯

Citations

Dec 7, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Piera BoschettoClaudio Ceconi
Jul 21, 2009·BMC Pulmonary Medicine·Pål H BrekkeVidar Søyseth
May 6, 2008·Proceedings of the American Thoracic Society·Neil MacIntyre, Yuh Chin Huang
Nov 26, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Esosa Odigie-OkonConstantine A Manthous
Dec 12, 2013·Internal and Emergency Medicine·Gregor LindnerAristomenis Konstantinos Exadaktylos
May 17, 2015·Expert Review of Respiratory Medicine·Janine PilcherRichard Beasley
Aug 3, 2010·COPD·Juan José Soler-Cataluña, Roberto Rodriguez-Roisin
Jan 20, 2016·The Lancet. Respiratory Medicine·Martin I MacDonaldRobert J Hancox
Aug 13, 2011·Chest·Angela KoutsokeraKonstantinos Kostikas
Dec 27, 2011·Archivos de bronconeumología·Marc MiravitllesJuan José Soler-Cataluña
Mar 25, 2008·The American Journal of Emergency Medicine·Shih-Hung TsaiShih-Ping Yang
Nov 10, 2006·Médecine et maladies infectieuses·K Faure
Feb 6, 2008·Journal of Interventional Cardiology·Luisa De GennaroMatteo Di Biase
Nov 18, 2005·International Journal of Cardiology·Nitin MahajanEdgar Lichstein
Apr 12, 2014·BioMed Research International·Cheryl R Laratta, Stephan van Eeden
Dec 2, 2006·Journal of Applied Physiology·Jeremy A Simpson, Steve Iscoe
May 2, 2009·Journal of Applied Physiology·Jeremy A SimpsonSteve Iscoe
Oct 22, 2020·Expert Review of Respiratory Medicine·Paola RoglianiLuigino Calzetta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.