Jan 1, 1990

Elevation of facilitated glucose-transporter messenger RNA in human hepatocellular carcinoma

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
T S SuC K Chou

Abstract

Complementary DNA of a rat brain glucose transporter gene was used to examine the expression of glucose-transporter messenger RNA in paired human hepatocellular carcinomas and adjacent nontumorous liver tissues, as well as in human hepatoma cell lines and human fetal liver samples. High expression of a major 2.8-kilobase glucose-transporter transcript was seen in all hepatoma cell lines and fetal liver samples examined, whereas a much lower level of expression was observed in liver tissues. When pairs of liver tissues were examined, elevation of glucose-transporter RNA levels was observed in most of the hepatocellular carcinoma tissues examined.

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Citations

Mentioned in this Paper

Liver Carcinoma
Gene Expression
Hepatocellular Carcinoma of the Mouse
Liver Parenchyma
Hexose Transporter
Membrane Transport Proteins
Fetal Liver
Northern Blot
DNA, Complementary
Rat Brain

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