Elevation of glucocorticoids is necessary but not sufficient for the escalation of cocaine self-administration by chronic electric footshock stress in rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
John R Mantsch, Eric S Katz

Abstract

The examination of cocaine self-administration (SA) by rats under conditions that promote escalating patterns of intake should lead to a better understanding of factors that contribute to cocaine addiction. This study investigated the ability of repeated daily exposure to a stressor, electric footshock (EFS), to escalate cocaine SA. Male Sprague-Dawley rats were trained to self-administer cocaine (0.5 mg/kg/inf, i.v.) by pressing a lever under a FR4 schedule during 2-h sessions comprised of four 30-min SA components. Repeated daily EFS consisting of shock sequences (3 x 0.6 mA, 100-ms duration, 1-s frequency) delivered under a variable time 45-s schedule for 5 min before each of the four SA components across 14 days of SA testing produced a significant escalation of cocaine SA. EFS failed to escalate food-reinforced lever pressing and did not alter cocaine SA when administered either inside or outside of the SA context 4 h after daily SA testing. Surgical adrenalectomy along with diurnal corticosterone (CORT) replacement prevented EFS-induced escalation without altering SA in the absence of EFS, indicating that increases in circulating glucocorticoids were necessary for the escalating effects of EFS. Elevation of CORT through r...Continue Reading

References

May 1, 1979·Physiology & Behavior·J S MeyerB S McEwen
Mar 1, 1989·American Journal of Epidemiology·J C AnthonyK R Petronis
Nov 1, 1996·Neuroendocrinology·N E Goeders, G F Guerin
Dec 1, 1996·Psychopharmacology·K A Miczek, N H Mutschler
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
May 6, 1999·Psychopharmacology·R SinhaS O'Malley
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·J R Mantsch, N E Goeders
Nov 1, 2000·Psychopharmacology·R SinhaS S O'Malley
Feb 13, 2001·Psychoneuroendocrinology·T W Buchanan, W R Lovallo
Jan 18, 2002·Psychopharmacology·R Sinha
Mar 22, 2002·Drug and Alcohol Dependence·Thomas R KostenAlan Feingold
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Nick E Goeders
Aug 24, 2002·The European Journal of Neuroscience·Michela Marinelli, Pier Vincenzo Piazza
Feb 1, 2003·Neurobiology of Learning and Memory·Benno Roozendaal
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·George F KoobPietro Paolo Sanna
Aug 18, 2004·Science·Véronique Deroche-GamonetPier Vincenzo Piazza
Mar 15, 2005·Stress : the International Journal on the Biology of Stress·Antonio ArmarioXavier Belda
Jun 14, 2005·Addictive Behaviors·Sudie E BackJoan L Jackson

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Citations

Oct 30, 2007·Psychopharmacology·Sheila E SpecioGeorge F Koob
Aug 7, 2013·Neuropharmacology·John R MantschJordan M Blacktop
Mar 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Evan N GrafJohn R Mantsch
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jack H MendelsonNancy K Mello
May 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John R MantschEric S Katz
Sep 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Harinder AujlaFriedbert Weiss
Mar 7, 2009·Psychopharmacology·Inge E M de JongE Ronald de Kloet
Dec 3, 2009·Psychopharmacology·Peter PutmanWillem A J van der Does
Jan 17, 2015·Physiology & Behavior·Andrew Chih Wei HuangCheng Chung Wang
Mar 13, 2012·Neuroscience and Biobehavioral Reviews·Adrie W Bruijnzeel
Sep 25, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniele CaprioliAldo Badiani
Apr 18, 2008·European Journal of Pharmacology·E Ronald de KloetMelly S Oitzl
Jun 25, 2014·Behavioural Brain Research·Christopher D SchmoutzNicholas E Goeders
Feb 14, 2007·Psychopharmacology·Daniele CaprioliAldo Badiani
Dec 18, 2013·Stress : the International Journal on the Biology of Stress·Jayme R McReynoldsJohn R Mantsch
Aug 26, 2018·The European Journal of Neuroscience·Sandra Montagud-RomeroMarta Rodríguez-Arias
Feb 12, 2011·Psychopharmacology·Arianna TestaAldo Badiani
Aug 25, 2020·Stress : the International Journal on the Biology of Stress·Natalie A HadadLori A Knackstedt
Jul 21, 2017·Psychopharmacology·Michael Z LeonardKlaus A Miczek
Mar 5, 2021·Journal of Neurochemistry·Aaron CaccamiseJohn R Mantsch
Nov 16, 2021·Frontiers in Behavioral Neuroscience·Kelsey M VollmerJames M Otis

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