PMID: 9181229Jun 1, 1997Paper

Elevation of glutathione and related enzyme activities in high-grade and metastatic extremity soft tissue sarcoma

Annals of Surgical Oncology
S N HochwaldM E Burt

Abstract

Glutathione is a free radical scavenger implicated in the chemoresistance of certain tumors. As treatment with chemotherapy has added little to improved survival in adult soft tissue sarcoma and little is known concerning the mechanisms of chemoresistance in sarcoma, we studied concentrations of glutathione (nmol/mg protein) and activities of gamma-glutamylcysteine synthetase (GCS; nmol/mg protein/h) and gamma-glutamyl transpeptidase (GGTP; U/mg protein) in extremity soft tissue sarcoma. Tumor specimens (n = 65) were frozen in liquid nitrogen at the time of resection. Fourteen low-grade tumors, 40 high-grade tumors, and 11 pulmonary metastases were analyzed. Glutathione concentrations and GGTP activity were significantly lower in low-grade (3.97 +/- 0.7 nmol/mg protein and 1.07 +/- 0.2 U/mg protein) than in high-grade (8.98 +/- 1.2 nmol/mg protein, p < 0.001; 2.10 +/- 0.4 U/mg protein, p < 0.002) tumors and pulmonary metastases (10.05 +/- 1.8 nmol/mg protein, p < 0.008; 3.14 +/- 2.8 U/mg protein, p < 0.04). While GCS activity was lower in low-grade (0.81 +/- 0.3 nmol/mg protein/h) than high-grade (1.49 +/- 0.5 nmol/mg protein/h) tumors and pulmonary metastases (1.03 +/- 0.2 nmol/mg protein/h), these differences were not signifi...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A K GodwinM E Anderson
Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J GaynorM F Brennan
Sep 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Cordon-CardoM R Melamed
Jan 18, 1989·Journal of the National Cancer Institute·L J GoldsteinG M Brodeur
Jul 1, 1989·American Journal of Surgery·M F Brennan
Sep 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A E ChangS M Steinberg
Jun 1, 1988·World Journal of Surgery·S I HajduM F Brennan
Jan 1, 1986·Journal of the American College of Nutrition·A MeisterO Hwang
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Feb 21, 1996·Journal of the National Cancer Institute·S N HochwaldM E Burt

❮ Previous
Next ❯

Citations

Jun 15, 2013·Oxidative Medicine and Cellular Longevity·Nicola TraversoCinzia Domenicotti
Apr 29, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·F YangJ Fu
Apr 30, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W-z HeL-p Xia
Jul 2, 2020·Signal Transduction and Targeted Therapy·Dingshan Li, Yongsheng Li
Mar 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rikke Illum HøghSøren Skov
Aug 8, 2017·International Journal of Molecular Sciences·Alessandro Fanzani, Maura Poli
Sep 21, 2016·Scientific Reports·Richard SchwameisMariella Polterauer
Jan 13, 2016·Critical Reviews in Clinical Laboratory Sciences·José M EstrelaElena Obrador
Mar 4, 2000·Free Radical Biology & Medicine·R G Allen, M Tresini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.