Elevation of HLA-G-expressing DC-10 cells in patients with gastric cancer

Human Immunology
Dan-Ping XuWei-Hua Yan

Abstract

DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In this study, the frequency and mean fluorescence intensity (MFI) of HLA-G+ DC-10 in the peripheral blood of 124 patients with gastric cancer (GC) and 130 normal controls was analyzed with flow cytometry. Plasma sHLA-G was analyzed with ELISA. Results showed both the percentages of peripheral HLA-G+ DC-10 (median: 0.13% vs 0.01%; p<0.01) and MFI of HLA-G on these cells (median: 310.0 vs 91.5; p<0.01) were dramatically increased in GC patients than in normal controls. The frequency of HLA-G+ DC-10 in GC patients was strongly relative to the tumor grade (p=0.021). sHLA-G levels in GC patients were significantly higher than in healthy controls (median: 85.80U/ml vs 61.20U/ml; p<0.01). There was no significant correlation between the percentage of DC-10 and plasma sHLA-G (p>0.05). However, the increased HLA-G+ DC-10, HLA-G MFI and plasma sHLA-G in patients with gastric cancer could be a diagnostic factor with the area unde...Continue Reading

References

Jun 18, 2009·Tissue Antigens·B-L LiW-H Yan
Dec 15, 2012·Human Immunology·Giada AmodioSilvia Gregori
Feb 2, 2013·Transplantation Research·Giada Amodio, Silvia Gregori
Apr 18, 2014·Journal of Immunology Research·Grazia LocafaroSilvia Gregori
Jun 3, 2014·Cytokine & Growth Factor Reviews·Fabio MorandiVito Pistoia
Aug 19, 2014·Tissue Antigens·G AmodioS Gregori
Aug 22, 2014·Journal of Immunology Research·Vera RebmannPeter A Horn
Dec 6, 2014·Frontiers in Immunology·Roberta RizzoEnrico Fainardi
Jan 24, 2015·Nature Reviews. Immunology·Takanori KitamuraJeffrey W Pollard
Feb 11, 2015·Haematologica·Giada AmodioSilvia Gregori

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Citations

Sep 22, 2016·Journal of Immunology Research·Fabio MorandiVito Pistoia
Nov 11, 2020·SN Comprehensive Clinical Medicine·Charu SonkarHem Chandra Jha
Feb 11, 2021·Trends in Cancer·Edgardo D CarosellaDiana Tronik-Le Roux

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