Elevation of intracranial pressure affects the relationship between hemoglobin concentration and neuronal activation in human somatosensory cortex.

Human Brain Mapping
Julia ThranitzGeorg Royl

Abstract

During neuronal activation, a local decrease of deoxygenated hemoglobin concentration (deoxy-Hb) occurs which is the basis of functional brain imaging with blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI). Elevated intracranial pressure (eICP) has been shown to impair functional deoxy-Hb changes. This study investigated this effect and its relation to the underlying neuronal activity in the human primary somatosensory cortex (SI). Functional near-infrared spectroscopy (fNIRS) during somatosensory evoked potentials (SEP) monitoring was performed on 75 subjects during conditions of median nerve stimulation (MNS) and resting state, combined with normal breathing (NB) and eICP by escalating breathing maneuvers (breath holding [BH], Valsalva maneuver with 15 mmHg [V15] and 35 mmHg expiratory pressure [V35]). During NB, fNIRS revealed a typical oxygenated hemoglobin concentration (oxy-Hb) increase with deoxy-Hb decrease during MNS enabling SI brain mapping. Breathing maneuvers associated eICP produced a known global change of oxy-Hb and deoxy-Hb with and without MNS. When subtracting measurements during resting state from measurements during MNS, neither functional oxy-Hb nor deoxy-Hb changes could ...Continue Reading

References

Jun 1, 1989·Electroencephalography and Clinical Neurophysiology·H SteinmetzB U Meyer
Jan 1, 1993·Electroencephalography and Clinical Neurophysiology·V L TowleJ P Spire
Sep 22, 1998·Electroencephalography and Clinical Neurophysiology·M R NuwerP Rappelsburger
May 29, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J SpiegelR D Treede
Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·W H BackesJ P Reulen
Dec 6, 2002·Journal of Neurophysiology·Luke A HendersonRonald M Harper
Mar 22, 2003·Science·Felix BlankenburgArno Villringer
Sep 24, 2005·Journal of Biomedical Optics·Hiroki SatoHideaki Koizumi
Jan 1, 1890·The Journal of Physiology·C S Roy, C S Sherrington
Nov 10, 2006·Human Brain Mapping·Daniel A HandwerkerMark D'Esposito
Aug 4, 2007·Minimally Invasive Neurosurgery : MIN·H PrabhakarH H Dash
Oct 2, 2007·NeuroImage·Moriah E Thomason, Gary H Glover
Feb 10, 2009·Current Alzheimer Research·Peter WostynPeter Paul De Deyn
Jul 16, 2013·Advances in Experimental Medicine and Biology·Atsuhiro TsubakiHideaki Onishi
Oct 24, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christoph Leithner, Georg Royl
Feb 5, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nizar KhatibIsrael Thaler
Jul 18, 2014·Annual Review of Neuroscience·Elizabeth M C Hillman
Feb 26, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paula WuDaniel A Handwerker
Dec 15, 2015·Acta Physiologica·L PstrasF Bellavere
May 1, 2016·Progress in Brain Research·K MasamotoI Kanno
Jul 5, 2016·Frontiers in Human Neuroscience·Muhammad A KamranMyung Yung Jeong
Nov 12, 2016·Computer Methods in Biomechanics and Biomedical Engineering·E J MathiasT David
May 12, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rebecca W PakArvind P Pathak

❮ Previous
Next ❯

Software Mentioned

Presentation®
MATLAB®

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.