Abstract
Apoptosis is reported to play an important role in left ventricular (LV) remodeling after acute myocardial infarction (AMI). Granzyme B is a member of the serine esterase family, which has an important role in cellular apoptosis and extracellular matrix degradation. Peripheral blood samples were obtained from 33 patients with a first-onset AMI treated by percutaneous coronary intervention (mean age: 61.4+/-8.7 years old) on days 1, 7 and 14 after onset. Plasma levels of tumor necrosis factor (TNF)-alpha, a soluble form of the Fas ligand (sFasL), and granzyme B were measured. TIMI grade 3 recanalization was accomplished in all patients within 12 h after onset. The LV end-diastolic volume index (LVEDVI) was calculated on day 1 and at 6 months after onset. Plasma levels of TNF-alpha, sFasL and granzyme B increased significantly on days 7 and 14 after onset of AMI. Stepwise multivariate regression analysis showed that the plasma granzyme B level on day 14 is a significant explanatory variable for changes in the LVEDVI. Plasma levels of granzyme B increased after AMI, which might be an important factor in the progression of late LV remodeling after AMI.
References
Nov 18, 1991·The American Journal of Cardiology·E Braunwald, M A Pfeffer
Jun 5, 1986·The New England Journal of Medicine·UNKNOWN I.S.A.M. Study Group
Jul 1, 1988·Circulation·H F WeismanB Healy
Oct 1, 1986·Circulation·R G McKayW Grossman
Dec 16, 1993·The American Journal of Cardiology·K A ReimerV J Richard
Aug 1, 1996·Experimental Cell Research·W ChengP Anversa
Feb 1, 1997·Immunity·A SarinP A Henkart
Apr 1, 1997·Circulation·G G Neri SerneriR Abbate
May 1, 1997·Journal of Molecular and Cellular Cardiology·L C KatwaK T Weber
May 1, 1997·Current Opinion in Cardiology·K ShanD L Mann
Jul 1, 1997·Cardiovascular Research
Jun 20, 1998·Circulation Research·G TakemuraH Fujiwara
Jul 1, 1998·The Annals of Thoracic Surgery·Y KageyamaY Harada
Jun 15, 1999·Circulation·L E RohdeR T Lee
Dec 13, 2000·Journal of Molecular and Cellular Cardiology·N Varda-BloomD Hasin
Aug 15, 2001·Circulation·N SivasubramanianD L Mann
Jun 25, 2003·Circulation·Kenji HayakawaHisayoshi Fujiwara
Nov 12, 2003·Circulation·Russell V LuepkerUNKNOWN National Heart, Lung, and Blood Institute
Dec 17, 2003·Circulation·John K NinomiyaRoland S Chen
Aug 7, 2004·Circulation Research·Yiwen LiHisayoshi Fujiwara
Apr 22, 2005·The Journal of Biological Chemistry·Marguerite S BuzzaPhillip I Bird
Jun 27, 2007·Heart·R TsuruT Yashiro
Mar 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Guldem MercanogluFrancesco Fici
Citations
Dec 7, 2013·Mediators of Inflammation·Hala O El-MesallamyEman F Wasfey
Nov 8, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hala O El MesallamyAshraf I Amin
May 6, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alon HendelDavid J Granville
Nov 10, 2013·PloS One·Paul R HiebertDavid J Granville
Feb 9, 2010·Cell Death and Differentiation·A HendelD J Granville
Apr 10, 2012·The American Journal of Cardiology·Marie FertinChristophe Bauters
Feb 8, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Alon HendelDavid J Granville
Jul 20, 2010·European Journal of Clinical Investigation·Arintaya PhrommintikulNipon Chattipakorn
Mar 11, 2011·Scandinavian Journal of Immunology·G LaskarinD Rukavina
Jun 12, 2010·Immunological Reviews·Desiree A AnthonyMark J Smyth
Apr 24, 2012·Journal of cardiology·Marie FertinChristophe Bauters
Nov 10, 2009·Neuroscience·G V ChaitanyaP Prakash Babu
Dec 21, 2010·Journal of cardiology·Yuji SaitoYukihiro Hojo
Jul 24, 2012·Journal of cardiology·Yukihiro HojoHideyuki Kondo
Apr 6, 2012·PloS One·Wendy A BoivinDavid J Granville
Jul 13, 2017·Biomarkers in Medicine·Youyou YanJunnan Wang
Sep 23, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wendy Anne BoivinDavid James Granville
Mar 30, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Roby JoehanesPeter J Munson
Apr 18, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lin YangBo Lei
Feb 16, 2018·Cell Death & Disease·Min MaoDaling Zhu
Jan 29, 2019·Frontiers in Cardiovascular Medicine·Icia Santos-ZasHafid Ait-Oufella
Dec 3, 2020·Frontiers in Immunology·Francesca VelottiMaria Gisella Cavallo
Mar 22, 2021·Journal of Molecular Graphics & Modelling·Saima IkramSerdar Durdagi
Oct 10, 2020·Cellular Signalling·Matthew R Zeglinski, David J Granville