Elevation of plasma granzyme B levels after acute myocardial infarction

Circulation Journal : Official Journal of the Japanese Circulation Society
Hideyuki KondoKazuyuki Shimada

Abstract

Apoptosis is reported to play an important role in left ventricular (LV) remodeling after acute myocardial infarction (AMI). Granzyme B is a member of the serine esterase family, which has an important role in cellular apoptosis and extracellular matrix degradation. Peripheral blood samples were obtained from 33 patients with a first-onset AMI treated by percutaneous coronary intervention (mean age: 61.4+/-8.7 years old) on days 1, 7 and 14 after onset. Plasma levels of tumor necrosis factor (TNF)-alpha, a soluble form of the Fas ligand (sFasL), and granzyme B were measured. TIMI grade 3 recanalization was accomplished in all patients within 12 h after onset. The LV end-diastolic volume index (LVEDVI) was calculated on day 1 and at 6 months after onset. Plasma levels of TNF-alpha, sFasL and granzyme B increased significantly on days 7 and 14 after onset of AMI. Stepwise multivariate regression analysis showed that the plasma granzyme B level on day 14 is a significant explanatory variable for changes in the LVEDVI. Plasma levels of granzyme B increased after AMI, which might be an important factor in the progression of late LV remodeling after AMI.

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Citations

Nov 8, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hala O El MesallamyAshraf I Amin
May 6, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alon HendelDavid J Granville
Feb 9, 2010·Cell Death and Differentiation·A HendelD J Granville
Apr 10, 2012·The American Journal of Cardiology·Marie FertinChristophe Bauters
Feb 8, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Alon HendelDavid J Granville
Jul 20, 2010·European Journal of Clinical Investigation·Arintaya PhrommintikulNipon Chattipakorn
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Dec 21, 2010·Journal of cardiology·Yuji SaitoYukihiro Hojo
Jul 24, 2012·Journal of cardiology·Yukihiro HojoHideyuki Kondo
Sep 23, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wendy Anne BoivinDavid James Granville
Mar 30, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Roby JoehanesPeter J Munson
Apr 18, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lin YangBo Lei
Jan 29, 2019·Frontiers in Cardiovascular Medicine·Icia Santos-ZasHafid Ait-Oufella
Oct 10, 2020·Cellular Signalling·Matthew R Zeglinski, David J Granville

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