Elevation of plasma placental growth factor in the patients with ischemic cardiomyopathy

International Journal of Cardiology
Tomohiro NakamuraSan-e Ishikawa

Abstract

Placental growth factor (PlGF), which is a member of the vascular endothelial growth factor family, stimulates angiogenesis and collateral growth in ischemic tissues. In addition, PlGF has been known to be a useful biomarker of vascular inflammation. This study was undertaken to examine whether plasma PlGF levels were increased in patients with congestive heart failure (CHF). Ninety-eight patients with systolic heart failure (ejection fraction <40%) and twenty control subjects were enrolled. The patients were divided into four subgroups according to the criteria of NYHA functional class. Plasma PlGF, tumor necrosis factor (TNF)-alpha, brain natriuretic peptide (BNP), norepinephrine, high-sensitive C-reactive protein (hs-CRP) were determined. In analysis of all the subjects, there was no significant difference in plasma PlGF levels among the subgroups of NYHA classes and the controls. In the ischemic cardiomyopathy (ICM) patients, however, plasma PlGF levels were significantly increased according to the severity of NYHA class; control: 8.9+/-0.5; NYHA I: 9.4+/-1.1, NYHA II: 9.7+/-1.9, NYHA III: 14.6+/-1.2, NYHA IV: 17.9+/-1.9 pg/ml (p=0.0006). Plasma PlGF levels correlated positively with BNP (r=0.53, p=0.0003) and hs-CRP (r=0.2...Continue Reading

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Citations

Oct 16, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrea CaporaliCostanza Emanueli
Jun 4, 2011·Circulation Research·Federica AccorneroJeffery D Molkentin
Mar 7, 2013·Endocrine-related Cancer·Georg HilfenhausChristian Fischer
Jun 19, 2013·International Heart Journal·Ryo KamedaTohru Izumi
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Aug 21, 2012·Trends in Cardiovascular Medicine·Federica Accornero, Jeffery D Molkentin
Nov 17, 2015·International Journal of Cardiology·Ming WuStefan Janssens
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Jul 17, 2013·Nature Reviews. Cardiology·Ziad TaimehRoberto Bolli
Apr 27, 2018·Frontiers in Physiology·Vincent F M SegersGilles W De Keulenaer
Mar 22, 2019·Frontiers in Cardiovascular Medicine·Rajinikanth GogirajuKatrin Schäfer
Feb 16, 2021·Frontiers in Immunology·Oluwabukola T GbotoshoGregory J Kato

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