Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia

American Journal of Hypertension
Jessica ThomasonMohammad Nasir Uddin

Abstract

Preeclampsia (preE), a syndrome of hypertension, proteinuria, and edema, has many elusive triggers. The renin-angiotensin system has been implicated in preE pathogenesis. In this study, we test the hypothesis that (pro)renin levels are increased in preE patients and that levels of (pro)renin and (pro)renin receptor ((P)RR) are elevated in a rat model of preE. We recruited 30 preE and 43 normal pregnant consenting patients. We used normally pregnant rats (NP, n = 10) and pregnant rats receiving weekly injections of desoxycorticosterone acetate and whose drinking water was replaced with 0.9% saline (preE, n = 10). Plasma and placental levels of (pro)renin were assayed by ELISA. Placental and kidney (P)RR was measured both by immunoblotting and immunohistochemistry. The mean plasma (pro)renin of 27.1±5.2 in preE patients differs from that in patients without preE: 14.8±5.2 ng Ang I/ml/hour (P < 0.0001). In rats, both plasma (NP: 22.7±4.3 and preE: 49.2±10.0 ng Ang I/ml/hour) and placental (NP: 152±24 and preE: 302±39 ng/g tissue) levels of (pro)renin were higher (P < 0.001) in preE compared to NP rats. (P)RR expression was greater (P < 0.05) in placental tissue of preE rats, while kidney (P)RR expression was similar. Elevated leve...Continue Reading

References

Jun 1, 1992·American Journal of Hypertension·M A BrownJ A Whitworth
Aug 1, 1987·The Journal of Clinical Endocrinology and Metabolism·F H DerkxM A Schalekamp
Aug 1, 1987·American Journal of Obstetrics and Gynecology·H S BrarW A Hsueh
Mar 1, 1996·Acta Obstetricia Et Gynecologica Scandinavica·T Lenz
May 1, 1996·Immunopharmacology·K KataokaN Yanaihara
Apr 9, 1998·Bioscience, Biotechnology, and Biochemistry·U M NasirY Nakamura
Aug 15, 2000·Placenta·A H NielsenK Poulsen
Dec 26, 2001·Biology of Reproduction·Yang XiaRodney E Kellems
Sep 10, 2002·Obstetrical & Gynecological Survey·Gabriella Pridjian, Jules B Puschett
Nov 27, 2002·Endocrine·David C MerrillK Bridget Brosnihan
Apr 10, 2003·The Journal of Biological Chemistry·Fumiaki SuzukiKazuo Murakami
Mar 9, 2005·American Journal of Physiology. Renal Physiology·Dinesh M Shah
Nov 24, 2005·Clinical and Experimental Hypertension : CHE·Monica Ianosi-IrimieJules B Puschett
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Atsuhiro IchiharaTadashi Inagami
May 15, 2007·Journal of the American Society of Nephrology : JASN·Yuki KaneshiroHiroshi Itoh
Jun 16, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Nabi A H M NurunFumiaki Suzuki
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·M Nasir UddinFumiaki Suzuki
Feb 6, 2009·American Journal of Nephrology·Mohammad N UddinJules B Puschett
Jun 13, 2009·Endocrinology·Lauren AntonK Bridget Brosnihan
Nov 21, 2009·Human Reproduction Update·K G PringleC T Roberts
Dec 18, 2009·American Journal of Nephrology·Mohammad Nasir UddinJules B Puschett
Jan 29, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ayumu YoshikawaTakaaki Senbonmatsu
Feb 25, 2011·Pharmacogenetics and Genomics·Christian OttRoland E Schmieder
Oct 25, 2011·Obstetrical & Gynecological Survey·Dahlia Raymond, Erika Peterson
Oct 10, 2012·Hypertension·Noriyoshi WatanabeAtsuhiro Ichihara

❮ Previous
Next ❯

Citations

Dec 26, 2016·Journal of Biochemistry·Tsutomu NakagawaFumiaki Suzuki
Jul 19, 2018·American Journal of Physiology. Renal Physiology·Kevin T YangJ David Symons
Mar 27, 2018·Journal of Diabetes Investigation·Atsuhiro Kanda, Susumu Ishida
Dec 25, 2015·American Journal of Physiology. Renal Physiology·Xiaohan LuTianxin Yang
Sep 8, 2020·Current Hypertension Reports·Premjith Gathiram, Jagidesa Moodley
Jan 19, 2018·Current Opinion in Nephrology and Hypertension·Qing Zhu, Tianxin Yang
May 3, 2021·Biology of Sex Differences·Bruna VisniauskasMinolfa C Prieto
Jul 22, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Akiko OhwakiHiroki Kurahashi
Jun 24, 2021·The Journal of Pharmacology and Experimental Therapeutics·Manman QinJun Yu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Mohammad Nasir UddinThomas J Kuehl
Clinical and Experimental Hypertension : CHE
Monica Ianosi-IrimieJules B Puschett
American Journal of Reproductive Immunology : AJRI
K P ConradD F Benyo
© 2021 Meta ULC. All rights reserved