Elevation of PTH and PTHrp induced by excessive fluoride in rats on a calcium-deficient diet

Biological Trace Element Research
Hui XuGuang-Sheng Li

Abstract

Study on the role of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrp) in the process of skeletal fluorosis, involved especially in calcium deficiency, is rare. We evaluated the level of serum PTH and mRNA expression of PTHrp in femur when rats were exposed to excessive fluoride with low-calcium diet. Wistar rats (n = 60) was divided into four groups, a control group, fluoride group, low-calcium group, and low-calcium fluoride group. The fluoride groups were treated with fluoride by drinking tap water containing 100 mg F-/L. The low-calcium diet contained 0.05% calcium. Serum was collected in the first, fourth, eighth, and 12th of phase for the detemination of PTH and Ca(2+). RNA extraction from femora was used to analyze the mRNA express of PTHrp, osteopontin (OPN), and osteocalcin (OCN) after 12 weeks of fluoride dosing. Results showed that serum PTH increased gradually with the extension of fluoride exposure, but Ca2+ decreased, both of which embodied a time-dependent relationship. Cotreatment of excessive fluoride with low-calcium diet largely stimulated the secretion of PTH. The low dietary calcium markedly increased mRNA expression of PTHrp in animals with fluoride treatment. Expression of OPN and ...Continue Reading

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Citations

Sep 15, 2010·Biological Trace Element Research·Banu Kale KorogluMehmet Numan Tamer
Dec 12, 2012·The British Journal of Nutrition·Priyanka ShankarArjun L Khandare
Dec 24, 2013·Environmental Toxicology and Pharmacology·Qi-bing ZengAi-hua Zhang
Oct 26, 2010·Biological Trace Element Research·Hui LiuGuang-sheng Li
Aug 9, 2012·Biological Trace Element Research·Chun-Yan HuHui Xu
Mar 8, 2013·Environmental Toxicology and Pharmacology·Wenpeng WangHuabing Li
Feb 11, 2020·Frontiers in Nutrition·Jun LiuDong-Hong Wang
Aug 10, 2020·Biological Trace Element Research·Priyanka ShankarSujata Khandare

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