Elevation of serum CD5L concentration is correlated with disease activity in patients with systemic lupus erythematosus

International Immunopharmacology
Xiaofei LaiLiping Zhang

Abstract

Systemic lupus erythematosus (SLE) is characterized by an autoantibody- and immune complex-mediated inflammatory disease. Since CD5-like (CD5L), also known as apoptosis inhibitor of macrophage (AIM), is as an apoptosis inhibitor that protects the survival of macrophages, T cells, and NKT against proapoptotic agents, which plays an important role in the pathogenesis of various inflammatory diseases, we investigated the possible aberrant production of CD5L and its clinical implications in SLE patients. We measured the serum concentration and ex vivo production of CD5L in 68 SLE patients and 60 sex- and age- matched control individuals using an enzyme-linked immunoabsorbent assay. Serum CD5L concentrations were significantly higher in SLE patients than in healthy control subjects. Increase in CD5L concentration correlated positively and significantly with SLE Disease Activity Index (SLEDAI) score in all SLE patients. Besides, CD5L titers were positively correlated with anti-double stranded DNA antibody (anti-dsDNA) titers, ESR and C-reactive protein (CRP) levels, and negatively correlated with complement 3 (C3) and C4 levels. Serum CD5L concentrations could be significantly decreased after effective treatment of SLE. In addition, ...Continue Reading

Citations

Mar 13, 2021·Frontiers in Immunology·Maria Carolina MatosPedro José Esteves

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