Elevation of serum creatine phosphokinase and its MB isoenzyme during normal labor and early puerperium

Acta Obstetricia Et Gynecologica Scandinavica
Y AbramovJ Schenker

Abstract

Chest pain or discomfort are infrequent complaints among women during labor and early puerperium, but when present they raise the suspicion of myocardial ischemia. The diagnosis of the latter is based upon serum elevatIon of certain enzymes, such as aspartate amino transferase, lactate dehydrogenase and creatine phosphokinase. Nevertheless, the normal patterns of these enzymes in the serum during labor and early puerperium have not been characterized well. To determine serum creatine phosphokinase, lactate dehydrogenase and aspartate amino transferase levels in late pregnancy, and throughout labor and early puerperium. Fifty women having normal pregnancies followed by uneventful vaginal deliveries were prospectively studied for serum lactate dehydrogenase, aspartate amino transferase and creatine phosphokinase including its MB isoenzyme before, during and after labor. Cardiac status was evaluated in all women using serial electrocardiographic and physical examinations. All women were found to have low to normal antepartum serum enzymes levels. However, during labor total creatine phosphokinase increased markedly, reaching a peak of 2-4 fold baseline levels 24 hours postpartum. It then declined gradually back to baseline. Nullip...Continue Reading

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Citations

Apr 26, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Suzanne LilkerEric Goldszmidt
Jul 20, 2014·Seminars in Perinatology·Amy L Turitz, Alexander M Friedman
Feb 13, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ali Ozgur ErsoyNuri Danisman
Nov 3, 2007·The Journal of Emergency Medicine·Daniel J EganH Range Hutson
Jan 23, 1999·American Journal of Obstetrics and Gynecology·S A ShivversS M Ramin
Jun 25, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·T Sattler, M Fürll
Jul 31, 2018·Open Heart·Takeshi UmazumeHisanori Minakami
Apr 9, 1998·The Medical Clinics of North America·E MasonR Powrie

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