PMID: 8941010Dec 1, 1996Paper

Elevation of serum levels of matrix metalloproteinase-2 and -3 as new predictors of recurrence in patients with urothelial carcinoma

Cancer
K GohjiM Nakajima

Abstract

The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. Serum levels of MMP-2 and MMP-3 in 146 healthy controls, 52 patients with superficial (noninvasive) and 35 patients with advanced (invasive or metastatic) bladder carcinoma, and 30 patients with advanced upper urothelial carcinoma (renal pelvis and ureter) were measured by a one-step sandwich enzyme assay. Among the 53 patients with advanced urothelial carcinoma who underwent complete resection, the 1- and 3-year disease free survival rates of patients with elevated serum levels of either or both of the enzymes were 51% and 19%, respectively, whereas those of patients with normal serum levels of these enzymes were much higher, 86% and 79%, respectively (P < 0.005). In pT2N0M0 and pT3N0M0 patients who underwent complete resection, the recurrence rate in those with preoperative elevated serum levels of either or both of the enzymes was significantly higher than that in patients with normal levels (75% vs. 8%; P < 0.001). The 1- and 3-year disease free survival rates of pT2N0M0 and pT3N...Continue Reading

References

Oct 15, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·K ObataT Hayakawa
Dec 1, 1990·Anti-cancer Drugs·G SavaG Mestroni
Jan 10, 1980·Nature·G Poste, I J Fidler
Feb 1, 1994·Japanese Journal of Cancer Research : Gann·K GohjiI J Fidler
Nov 30, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·N FujimotoT Hayakawa

❮ Previous
Next ❯

Citations

Feb 19, 2013·Future Oncology·Mehrnoosh DoroudchiAbbas Ghaderi
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roopali RoyMarsha A Moses
Jan 21, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Henni RuokolainenTaina Turpeenniemi-Hujanen
Jul 4, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·Y NojiH Mabuchi
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Pia Vihinen, Veli-Matti Kähäri
Aug 2, 2012·ISRN Urology·O Rodriguez FabaF J Vizoso
Jan 4, 2012·Proteomics. Clinical Applications·Peter Findeisen, Michael Neumaier
Aug 5, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tobias BenoitCédric Poyet
Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·P J BoströmM Laato
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·K GohjiM Nakajima
Aug 9, 2001·International Journal of Cancer. Journal International Du Cancer·K GohjiM Nakajima
Jan 15, 2014·Proteomics. Clinical Applications·Randa Ali-LabibMarwa Tarek
Oct 23, 1998·The Journal of Urology·A KuglerR H Ringert
Nov 22, 2007·European Journal of Haematology·Heli PennanenTaina Turpeenniemi-Hujanen
Dec 12, 2007·Medical Oncology·Ayla AcarHaldun Guner
Jun 25, 2010·Annals of Surgical Oncology·Priyanka SrivastavaRama D Mittal
Apr 14, 2011·Nature Reviews. Urology·Tibor SzarvasHerbert Rübben
Nov 20, 2004·Urological Research·Stephen G Williams, John P Stein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.