Elevation of serum potassium during beta blockade: absence of relationship to the renin-aldosterone system

Clinical Pharmacology and Therapeutics
Y M TraubS Treuherz

Abstract

Eighteen patients with essential hypertension were treated in a single-blind, crossover study with pindolol and with propranolol. The two drugs were compared because of known differences between them on renin secretion. We noted that plasma renin activity and plasma aldosterone concentration were suppressed by propranolol but not by pindolol. Blood pressure was reduced about equally by both drugs. Serum potassium levels rose in 17 patients on pindolol (p < 0.001) and in 14 patients on propranolol (p = 0.08). Our data suggest that serum potassium elevations induced by beta blockade do not depend on the renin-angiotensin-aldosterone system. Alternative possibilities are discussed.

Citations

Jan 1, 1992·Journal of Clinical Pharmacology·S G ChrysantC Steiner
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·P Lundborg
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·M A van BaakJ F Smits
Dec 1, 1984·Journal of Endocrinological Investigation·M MontielM Morell
Jan 1, 1987·Acta Medica Scandinavica·L KayserJ E Mølholm Hansen
Jan 1, 1984·European Journal of Clinical Pharmacology·S R SmithS Laugher
Nov 5, 1997·Journal of General Internal Medicine·M A Perazella, R L Mahnensmith
Jan 13, 2006·The Journal of Clinical Hypertension·Domenic A Sica
Jun 1, 1993·Journal of Autonomic Pharmacology·M ReverteJ Moratinos
Jul 3, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Matthew A WeirAmit X Garg
Sep 21, 2000·The American Journal of Medicine·M A Perazella
Jul 1, 1986·Kidney International·R S Brown

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.