PMID: 7545095Sep 1, 1995Paper

Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma

Clinical and Experimental Immunology
A KoizumiT Horie

Abstract

We have previously shown the elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) in patients with bronchial asthma during asthma attacks. In the present study, we extended our earlier study by measuring serum sVCAM-1 levels by ELISA in 45 patients with bronchial asthma (23 atopic and 22 non-atopic) during asthma attacks and in stable conditions in order to assess further the state of adhesion molecules in allergic inflammation of bronchial asthma. The levels of sVCAM-1 in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These findings were observed regardless of atopic status. To examine the regulatory mechanism in the elevation of serum sVCAM-1 levels, serum tumor necrosis factor-alpha (TNF-alpha) levels were measured by ELISA. TNF-alpha levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. The nature of change in serum TNF-alpha levels correlated with the nature of change in serum sVCAM-1 levels, but serum TNF-alpha levels did not correlate with serum sVCAM-1 levels. These results suggest that higher levels of sVCAM-1 during asthma attacks may reflec...Continue Reading

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Citations

Jul 25, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·K Oymar, R Bjerknes
Jun 30, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R V AlbuquerqueP N Lesouëf
Mar 29, 2002·Pediatric Pulmonology·Ren-Bin TangRuey-Lung Chung
May 15, 1998·The British Journal of Dermatology·A WolkerstorferA P Oranje
Mar 16, 2002·European Journal of Human Genetics : EJHG·John S WitteJeff M Hall
Oct 12, 2004·Immunology and Allergy Clinics of North America·K Suresh BabuStephen T Holgate
Sep 19, 2021·The Journal of Allergy and Clinical Immunology·Melissa A RosenkranzWilliam W Busse

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