PMID: 6161583Dec 1, 1980Paper

Elevation of serum triglyceride levels from oral isotretinoin in disorders of keratinization

Archives of Dermatology
R A KatzT Nigra

Abstract

Ten patients with disorders of keratinization were treated with oral isotretinoin (13-cis-retinoic acid) on an investigational protocol to test the efficacy, safety, and optimal dosage schedule for using the drug in these rare disorders. Elevations of serum triglyceride levels above the highest normal levels developed in seven of the ten patients, while they maintained normal levels of serum cholesterol. This effect was found to be dose and/or time related and reversible. Moderate elevations of serum triglyceride levels have not been clearly established as a risk factor for the development of coronary artery disease. High levels, however, may precipitate acute pancreatitis. For this reason, the conditions of patients receiving retinoids must be carefully monitored for triglyceride abnormalities throughout their courses of treatment.

Citations

Nov 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·J R MarsdenS Shuster
Jan 1, 1989·Pharmacology & Therapeutics·J R Marsden
Oct 17, 1985·The New England Journal of Medicine·S BershadW V Brown
Nov 1, 1982·Journal of the American Academy of Dermatology·L M MilstoneR C Ablow
May 1, 1989·The American Journal of Medicine·A S Boyd
Apr 1, 1985·The Journal of Dermatologic Surgery and Oncology·H H RoenigkC W Hanke
Apr 1, 1982·Journal of the American Academy of Dermatology·L E Gerber, J W Erdman
Apr 1, 1982·Journal of the American Academy of Dermatology·D B Windhorst, T Nigra
Apr 1, 1982·Journal of the American Academy of Dermatology·J A GoldsteinJ S Strauss
Apr 1, 1982·Journal of the American Academy of Dermatology·G PlewigH H Wolff
Jul 1, 1981·Lipids·L E Gerber, J W Erdman
Jan 24, 2006·Archives of Dermatological Research·Miguel Angelo De MarchiDorotéia R S Souza
Jan 1, 1984·Archives of Dermatological Research·R HennesH J Vogt

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